medigraphic.com
ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2019, Number 1

<< Back Next >>

Rev Cubana Hematol Inmunol Hemoter 2019; 35 (1)

Platelet antibodies in cuban patients waiting for renal transplantation

Soler NG, Romero DY, Bencomo HA

Language: Spanish
References: 19
Page: 1-8
PDF size: 146.60 Kb.


ABSTRACT

Introduction: Platelet-specific antigens, known as human platelet antigens (HPA), are included within the spectrum of non-HLA histocompatibility antigens, because HPA antibodies participate in the rejection of transplantation, besides being a cause of the phenomenon of platelet refractoriness.
Objective:<7b> To characterize antibodies against platelet-specific antigens in Cuban patients awaiting kidney transplantation.
Methods: The technique “monoclonal antibodies immobilized platelets antigens" was applied to blood samples from 901 patients.
Results: HPA antibodies were detected in 78 patients, which in 87.17 % recognized the antigens present in the GP-IIb / IIIa complex. These antibodies were in 78.2 % of the IgG class, in 11.53 % IgA and IgM in 46.15 %.
Conclusions: HPA antibodies, mostly of the IgG class and directed to antigens present in the GP-IIb/IIIa complex, are common in Cuban patients awaiting kidney transplantation.


REFERENCES

  1. Tsuno NH, Matsuhashi M, Lino J, Nagura Y, Okazaki H, Santoso S. The importance of platelet antigens and antibodies in immune-mediated thrombocytopenia. Vox Sang. 2014;9:104-11. [ Links ]

  2. Curtis BR and McFarland JG. Human platelet antigens- 2013. Vox Sang. 2014;106:93-102. DOI: 10.1111/vox.12085. [ Links ]

  3. Gorgi YI, Sfar T, Ben Abdallah H, Aouadi E, Abderrahim R, Bardi S, et al. Human platelet antigens: HPA-1, -2, -3, -4, and -5 polymorphisms in kidney transplantation. Transplant Proc. 2007;39(8):2568-70. DOI: 10.1016/j.transproceed.2007.08.032 [ Links ]

  4. Murphy MF. Managing the platelet refractory patient. ISBT Science Series. 2014;9:234-8. [ Links ]

  5. Lee C, Ayob Y. Approach to managing platelet refractory patients. ISBT Science Series. 2015;10(S1):1751-2824. [ Links ]

  6. Aquino Rojas S, Soler Noda G, Bencomo Hernández A. Refractariedad plaquetaria: acercamiento al diagnóstico. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2017 [citado: 19/12/2017];33(4):[aprox. 0 p.]. Disponible en: http://www.revhematologia.sld.cu/index.php/hih/article/view/519 [ Links ]

  7. Jia Y, Li W, Liu N, Zhang K, Gong Z, Li D, et al. Prevalence of platelet-specific antibodies and efficacy of crossmatch-compatible platelet transfusions in refractory patients. Transfus Med. 2014;24:406-410. DOI:10.1111/tme.12157. [ Links ]

  8. Hayashi T, Hirayama F. Advances in alloimmune thrombocytopenia: perspectives on current concepts of human platelet antigens, antibody detection strategies, and genotyping. Blood Transfus. 2015;13(3):380-90. DOI: 10.2450/2015.0275-14 [ Links ]

  9. Millum J, Wnedler D, Emanuel EJ. The 50th anniversary of the Declaration of Helsinki. Progress but many remaining challenges. Jama. 2013;310(20):2-143. [ Links ]

  10. Peterson J, Pechauer S, Gitter M, Kanack A, Curtis B, Reese J, et al. New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia. Transfusion. 2012;52:1117-24. DOI: 10.1111/j.1537-2995.2011.03428.x [ Links ]

  11. Klein HG, Anstee DJ. Mollison's Blood Transfusion in Clinical Medicine. 2014:12th ed. Chichester: The Atrium;2014.p. 610. [ Links ]

  12. Sareban N, Macher S, Drexler C, Posch U, Lanzer G, Schallmoser K. Platelet antibody analysis by three different tests. J Clin Lab Anal. 2015;29(3):198-202. DOI: 10.1002/jcla.21750 [ Links ]

  13. Jia Y, Li W, Liu N, Zhang K, Gong Z, Li D, et al. Prevalence of platelet-specific antibodies and efficacy of crossmatch-compatible platelet transfusions in refractory patients. Transfus Med. 2014;24(6):406-10. DOI: 10.1111/tme.12157 [ Links ]

  14. Younesi MR, Louni S, Bigdeli R, Lashgari M, Mazaheri H, Asgary V. Alloimmunization against platelets, granulocytes and erythrocytes in multi-transfused patients in Iranian population. Transfus Apher Sci. 2016;14(16):64-7. DOI: 10.1016/j.transci.2016.06.003 [ Links ]

  15. Maslanka K, Michur H, Guz K, Wróbel A, Uhrynowska M, Misiak A, et al. The relevance of HPA-15 antigen expression for anti-HPA-15 antibody detection. Int J Lab Hematol. 2012;34(1):65-9. DOI: 10.1111/j.1751-553X.2011.01358.x [ Links ]

  16. Sarkar RS, Philip J, Jain N. Detection and Identification of Platelet-Associated Alloantibodies by a Solid-Phase Modified Antigen Capture Elisa (MACE) Technique and Its Correlation to Platelet Refractoriness in Multi platelet Concentrate Transfused Patients. Indian J Hematol Blood Transfus. 2015;31(1):77-84. DOI: 10.1007/s12288-014-0374-4. [ Links ]

  17. Rich RR. The human immune response. En: Rich RR, Fleisher TA, William T, Shearer WT, Schroeder HW, Anthony J. Clinical immunology. Principles and practice. 4th. Ed. London:Elsevier;2013. p. 3-15. [ Links ]

  18. Puga I, Cerutti A, Montserrat C. Modulación del cambio de isotipo de las inmunoglobulinas por señales del sistema inmunitario innato. Semin Fund Esp Reumatol. 2013. DOI:10.1016/j.semreu.2013.09.003. [ Links ]

  19. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 9th ed. San London:Elsevier;2017. [ Links ]




2020     |     www.medigraphic.com