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2019, Number 3

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Dermatología Cosmética, Médica y Quirúrgica 2019; 17 (3)

Acute Drug Reactions in Children. Prevalence in a High-Specialties Hospital in Mexico

Zaragoza Mora JI, Martínez-Herrera E, Monroy-Prado GA, Torres-Páez ÓU, Pinto-Almazán R

Language: Spanish
References: 13
Page: 161-165
PDF size: 120.40 Kb.


ABSTRACT

Background: drug reactions are polymorphic and usually affect all races and ages groups without distinction. There is not enough information on its prevalence in the Mexican pediatric population.
Objectives: to determine the prevalence of cutaneous lesions due to drugs and to identify the main associated drugs in pediatric patients. Study was carried out at the Dermatology Service in the Hospital Regional de Alta Especialidad de Ixtapaluca.
Materials and methods: cross-sectional and retrospective study in charge of Dermatology and Allergy Services that included patients from hospitalization, outpatient and emergency the between January 1, 2016 and December 31, 2018 according to a non-probabilistic count of consecutive cases.
Results: adverse drug reactions corresponded to 1.1% of pediatric patients treated by the Dermatology Service. The majority between six and 12 years old (41.4%). And 62% were men. The maculopapular, exanthematic and exfoliative reactions were the most frequent (48%), followed by fixed drug eruption (17.2%). The drugs most commonly involved were the antibiotics of the penicillin group. There was no report of associated deaths.
Conclusions: the prevalence of drug adverse reactions was 1.7%. 62% were men and 38% women. The highest percentage was presented by the group between six and 12 years of age.


REFERENCES

  1. NOM-220-SSA1-2002 Instalación y Operación de la Farmacovigilancia, Diario Oficial de la Federación, 15 de noviembre de 2004, México. Disponible en: http://www.dof.gob.mx/nota_detalle.php?codigo= 490830&fecha=19/07/2017.

  2. Salazar JJ, León-Quintero G y Arenas R, Dermatosis por medicamentos. En Ruiz Maldonado R, Parish C y Beare JM, Tratado de dermatología pediátrica, México, Interamericana-McGraw-Hill, 1992, pp. 609-619.

  3. Severino G y Del Zombo M, Adverse drug reactions: role of pharmacogenomics, Pharmacological Research 2004; 49:363-73.

  4. Chávez F, Reynoso C y Rodríguez N, Prevalencia de las farmacodermias en pacientes hospitalizados en el Servicio de Dermatología de la umae del Centro Médico Nacional de Occidente. Periodo 2004-2012, Dermatol Rev Mex 2014; 58:339-45.

  5. Ramírez-Reyna A, Frecuencia de presentación de farmacodermias en pacientes en el Servicio de Urgencias del Hospital Infantil de México Federico Gómez, tesis digital, Universidad Nacional Autónoma de México, febrero de 2013. Disponible en: http://oreon.dgbiblio.unam. mx/F?RN=554879442.

  6. Rotela V, Valiente C, Di Martino B, Rodríguez M y Bolla L, Farmacodermias, cimel 2016; 21(2):42-7.

  7. Weedon D, Cutaneus drug eruption. En Weedon’s Skin Pathology, 3ª ed., Londres, Churchill Livingstone Elsevier, 2010, pp. 511-23.

  8. Llamas Velasco M, Farmacodermias, Medicine 2010; 10(47):3123-30.

  9. Arenas Guzmán R, Dermatología. Atlas, diagnóstico y tratamiento, 5ª ed., México, Interamericana-McGraw-Hill, 2013, pp. 68-75.

  10. Kliegman R, Behrman R, Jenson H y SB Nelson, Tratado de pediatría. En Crecimiento, desarrollo y conducta. Infancia media, 18ª ed., México, Elsevier, pp. 57-60.

  11. Pichler WJ, Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept, Curr Opin Allergy Clin Immunol 2002; 2:301.

  12. Sharman VK y Dhar S, Clinical pattern of cutaneous drug eruption among children and adolescents in north India, Pediatric Dermatology 1995; 12:178-83.

  13. Harr T y French LE, Toxic epidermal necrolysis and Stevens-Johnson syndrome, Orphanet J Rare Dis 2010; 5:39.




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