Applications of cell replacement therapies to the treatment of poly-glutamine diseases

Luis Enrique Almaguer Mederos; Dany Cuello Almarales; Dennis Almaguer Gotay; Raúl Aguilera Rodríguez

2018, Number 4

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Rev Cubana Invest Bioméd 2018; 37 (4)

Applications of cell replacement therapies to the treatment of poly-glutamine diseases

Almaguer MLE, Cuello AD, Almaguer GD, Aguilera RR

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Language: Spanish
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ABSTRACT

A review of the specialized literature was carried out with the aim of evaluating the state of the art regarding the application of cell replacement therapies in polyglutamine diseases. The HighWire and PubMed databases were consulted, with the use of Boolean descriptors and operators. 84 articles were retrieved on the subject, published in journals with an average impact factor of 5.42. The experimental and pre-clinical studies carried out in relation to cell replacement therapies in polyglutamine diseases are discussed. The effectiveness of the use of stem cells from different sources in the improvement of motor function in experimental models of polyglutamine diseases is demonstrated. The need to perform multicenter studies in the medium and long term is revealed, for the evaluation of the therapeutic effects of cell replacement therapies in polyglutamine diseases.