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ISSN 1561-3011 (Electronic)

2019, Number 3

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Rev Cubana Invest Bioméd 2019; 38 (3)

IgG anti-Toxoplasma gondii antibody index as a measure of the naturally-acquired immune intrathecal response in a neuroepidemiological study

Cruz QM, Castillo GW, Dorta CAJ

Language: English
References: 10
Page: 1-10
PDF size: 334.71 Kb.


ABSTRACT

Introduction: The presence of IgG anti-Toxoplasma gondii has been used as an indicator to measure the naturally-acquired immune intrathecal response due to the polyclonal and polyspecific intrathecal response developed in neuroinflammation processes. The absence of anti-Toxoplasma gondii antibodies in a subject who had been exposed to the parasite could be seeded as immunocompromised. The aim of the study is determine cases of autoimmunity and immunodeficiency.
Objective: Demonstrate whether the IgG anti-Toxoplasma gondii antibody index can be used as an indicator of a population immune status seen through patients with neuroinflammatory processes.
Methods: Cerebrospinal fluid (CSF) and serum samples were taken from 64 pediatric patients with intrathecal synthesis of antibodies and IgG anti-Toxoplasma gondii antibody indexes (AI) were determined.
Results: The sample was divided in three intervals according to Hansotto Reiber investigations (≤0.6; 0.6-1.5; ≥1.5) and a mean interval ±1SD between 0.23 and 1.12. The groups were quite similar regarding to clinic and demographic characteristics; there were statics differences on anti-Toxoplasma gondii AI (p < 0.01) and the presence of domestic animals (p=0.04). In the group with AI≥1.5, the 83.3% had positive the Measles-Rubella- Zoster reaction, indicative of active autoimmune disease. On the group with AI≤0.6 were analyzed six different variables trying to find possible cases with immunodeficiencies: risk factors to contract toxoplasmosis; subjective clinical of immunocompromise; a test to detect immunodeficiencies; response against vacunal antigens and humoral response determined by IgG levels in serum. The immunodeficiencies test was the variable with higher statistical significance (p= 0.047).
Conclusions: The conclusion was that is possible to find subjects with autoimmune disorder and other ones with immunocompromise through the IgG anti-Toxoplasma gondii index by the developed investigation strategy.


REFERENCES

  1. Hansotto R. Knowledge-base for interpretation of Cerebrospinal fluid data patterns-Essentials in Neurology and Psychiatry. Arq Neuro-Psiquiatr. 2016 [acceso 13/01/2019];74(6):501-12. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27332077

  2. Hottenrott T, Dersch R, Berger B, Endres D, Huzly D, Thiel J, et al. The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis. BMC Neurology. 2018 [acceso 13/01/2019];18(1):14. Disponible en: https://doi.org/10.1186/s12883-018-1018-3

  3. Carellos EVM, de Andrade GMQ, Vasconcelos-Santos DV, Januário JN, Romanelli RMC, Abreu MNS, et al. Adverse socioeconomic conditions and oocyst-related factors are associated with congenital toxoplasmosis in a population-based study in Minas Gerais, Brazil. PloS one. 2014 [acceso 10/01/2019];9(2):e88588-e. Dispoible en: https://www.ncbi.nlm.nih.gov/pubmed/24523920

  4. Laboudi M. Review of toxoplasmosis in Morocco: seroprevalence and risk factors for toxoplasma infection among pregnant women and HIV- infected patients. The Pan African medical journal. 2017 [acceso 10/01/2019];27:269. Disponible en: http://www.panafrican-med-journal.com/content/article/27/269/full/

  5. Retmanasari A, Widartono BS, Wijayanti MA, Artama WT. Prevalence and Risk Factors for Toxoplasmosis in Middle Java, Indonesia. EcoHealth. 2017 [acceso 10/01/2019];14(1):162-70. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27830388

  6. Grandía R, Entrena A, Cruz J, Ginorio D, Domenech I, Alfonso A, et al. Seroprevalencia de toxoplasma gondii en felis catus en la Habana. Rev investig vet Perú. 2013 [acceso 14/01/2019];24(3). Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1609-91172013000200001&nrm=iso

  7. Baxevanis CN, Perez SA. Cancer Dormancy: A Regulatory Role for Endogenous Immunity in Establishing and Maintaining the Tumor Dormant State. Vaccines. 2015 [acceso 13/01/2019];3(3):597-619. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/26350597 https://www.ncbi.nlm.nih.gov/pmc/PMC4586469/

  8. Martín Peinador Y, Jiménez Alés R, Suárez Rodriguez A, Berghezan Suarez A, Morillo Gutierrez BD. Niño con infecciones recurrentes. Guía de Algoritmos en Pediatría de Atención Primaria; 2016 [acceso 12/01/2019]. Disponible en: https://algoritmos.aepap.org/adjuntos/infecciones_recurrentes.pdf

  9. Castillo González W, González Losada C, Iglesias González IM, Dorta Contreras AJ. Pesquisa inmuno-epidemiológica en niños con meningoencefalitis vírica vacunados contra la parotiditis, rubeola y sarampión. Vaccimonitor. 2019 [acceso 14/01/2019];28:19-28. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-028X2019000100019&nrm=iso

  10. Castillo Leyva Y, Alonso Remedios A, de Lara GarcÃa G, Pardo MartÃnez D, Vera Razumova A. Signos de alarma para el diagnóstico de las inmunodeficiencias primarias. Una propuesta adaptada a la provincia de Cienfuegos. MediSur. 2017 [acceso 04/01/2019];15:884-7. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2017000600018&nrm=iso




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