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Revista Cubana de Medicina Tropical

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2019, Number 2

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Rev Cubana Med Trop 2019; 71 (2)

Atypical presentation of non-Hodgkin's lymphoma in a patient with AIDS

Fonseca MCA, Ávila CJA, Fonseca GCM, Larrea FRR, Mederos HJ, Fernández MH
Full text How to cite this article

Language: Spanish
References: 20
Page: 1-11
PDF size: 260.99 Kb.


Key words:

non-Hodgkin's lymphoma, ophthalmoplegia, AIDS.

ABSTRACT

Non-Hodgkin's lymphoma is the second most common neoplasm in patients with AIDS. Its systemic clinical forms associated with the human immunodeficiency virus almost always have a high degree of malignancy. Involvement of the central nervous system is a frequent occurrence in patients with this type of lymphoma. The purpose of the study is to describe an atypical presentation of non-Hodgkin's lymphoma in a patient with AIDS. A case is reported of a male 28-year-old HIV-positive patient with diffuse large B-cell non-Hodgkin's lymphoma who presented with isolated cranial nerve III palsy as the main initial manifestation. The disease progressed rapidly and had a fatal outcome some days later. It is concluded that it is necessary to consider the diagnosis of non-Hodgkin's lymphoma in patients with AIDS and cranial nerve III palsy, in order to make an early diagnosis and initiate timely treatment, in view of the rapid evolution and poor prognosis of the disease.


REFERENCES

  1. Hoffmann C. Malignant Lymphomas. 2a ed. Alemania: Schröders Agentur; 2015. p. 420-8.

  2. Barta SK, Joshi J, Mounier N, Xue X, Wang D, Ribera JM, et al. Central nervous system involvement in AIDS-related lymphomas. Br J Haematol. 2016;173(6):857-66.

  3. Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013;13:487-98.

  4. Hocqueloux L, Avettand-Fènoël V, Jacquot S, Prazuck T, Legac E, Mélard A, et al. Long-term antiretroviral therapy initiated during primary HIV-1 infection is the key to achieving both low HIV reservoirs and normal T cell counts. J Antimicrob Chemother. 2013;68:1169-78.

  5. Perbost I, Malafronte B, Pradier C, Santo LD, Dunais B, Counillon E, et al. In the era of highly active antiretroviral therapy, why are HIV-infected patients still admitted to hospital for an inaugural opportunistic infection? HIV Med [Internet]. 2005 [citado el 3 de marzo de 2017];6(4):232-9. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/16011527

  6. Rucker JC, Thurtell MJ. Cranial neuropathies. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016.

  7. Bhatti MT, Schmalfuss IM, Eskin TA. Isoleted cranial nerve III palsy as the presenting manifestation of HIV-related large B-cell lymphoma: clinical, radiological and postmortem observations. Surv Ophtalmol [Internet]. 2005 [citado el 3 de marzo de 2017];50:598-606. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/16263372

  8. Pozo A, Pozo DR, Hernández M, Sayú JM. Parálisis criptogénica del III par craneal. Rev Cubana Pediatr. 2013;85(2): 14-7.

  9. Ortega G, Sierra J. Linfoma no Hodgkin en pacientes con SIDA. Presentación de un caso. Rev Mex Oftalmol. 2009;83(2):110-2.

  10. Snell, Richars S. Los núcleos de los nervios craneales, sus conexiones centrales y su distribución. Neuroanatomía Clínica. 6ª ed. Buenos Aires: Médica Panamericana.. 2007. p. 357-69.

  11. Fonseca C, Alfonso Y. Neurosida. En: Dorta A. Neuroinmunología Clínica. Cuba: Editorial Ciencia y Salud; 2009. p.113-30.

  12. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America [citado el 6 de marzo de 2017]. Disponible en: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf

  13. Swaminathan S, Padmapriyadarsini C, Narendran G. HIV-associated tuberculosis: clinical update. Clin Infect Dis. 2010;50:1377-86.

  14. Boulware DR, Meya DB, Muzoora C, COAT Trial Team. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med. 2014;370:2487-98.

  15. Ghanem KG, Moore RD, Rompalo AM, Erbelding EJ, Zenilman JM, Gebo KA. Neurosyphilis in a clinical cohort of HIV-1-infected patients. AIDS. 2008;22(10):1145-1151.

  16. Gibson TM, Morton LM, Shiels MS, Clarke CA, Engels EA. Risk of non-Hodgkin lymphoma subtypes in HIV infected people during the HAART era: a population-based study. AIDS. 2014;28:2313-8.

  17. Eichler AF, Batchelor TT. Primary central nervous system lymphoma: presentation, diagnosis and staging. Neurosurg Focus. 2006;15:21. 18. Leruez-Ville M, Seng R, Morand P, Boufassa F, Boue F, Deveau C, et al. Blood Epstein-Barr virus DNA load and risk of progression to AIDS-related systemic B lymphoma. HIV Med. 2012;13:479-87.

  18. British HIV Association guidelines for HIV-associated malignancies. HIV Medicine. 2014;15(Suppl. 2):1-92.

  19. Glass J. Neurologic complications of lymphoma and leukemia. Semin Oncol. 2006;33 (3):342-7.

  20. Li C, Li L, Zhang P, Zhang JS, Gao T, Xu Y, et al. Multifocal extranodal lymphoma: A case report. Medicine (Baltimore) [Internet]. 2016 [citado el 5 de marzo de 2017];95(40):e5029. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27749564




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Rev Cubana Med Trop. 2019;71