Lorenzo VN, Suarez OS

Language: Spanish
References: 16
Page: 1-11
PDF size: 163.45 Kb.

ABSTRACT

Acute Q fever is a ubiquitous zoonosis which often presents with self-limited febrile episodes. In the presence of a septic episode with manifestations of multiple organ dysfunction, cholestatic hepatitis, respiratory distress or renal failure as the prevailing semiology, and negative culture results, leptospirosis is usually suspected. The high prevalence of Q fever cases requiring evaluation at the Internal Medicine Service of Doctor Negrín University Hospital in Gran Canaria –about 50 cases per year in an area of 400 000 inhabitants– led to the indication of serological tests for Q fever and leptospirosis in septic cases with negative culture results. In the last six years, three cases have been found of Q fever simulating leptospirosis. A rapid response to the association of steroids and doxycycline was the common feature of these three cases. The study was aimed at describing the global context of the rapid response to the treatment indicated.

REFERENCES

1. Stein A, Saunders NA, Taylor AG. Phylogenic homogeneity of Coxiella burnetii strains as determinated by 16S ribosomal RNA sequencing. FEMS Microbiol Lett. 1993;113:339-44.

2. Kumsa B, Socolovschi C, Almeras L, Raoult D, Parola P. Occurrence and Genotyping of Coxiella burnetii in Ixodid Ticks in Oromia, Ethiopia. Am J Trop Med Hyg. 2015;93(5):1074-81. DOI: 10.4269/ajtmh.14-0758

3. Pérez-Arellano JL, Carranza Rodríguez C, Gutierrez C, Bolaños Rivero M. Epidemiología por fiebre Q en España (2018). Rev Esp Quimioter. 2018;31(5):386-405.

4. Araujo-Meléndez J, Sifuentes-Osornio J, Bobadilla-del-Valle JM, Aguilar-Cruz A, Torres-Angeles O, Ramírez-González JL, et al. What do we know about Q fever in Mexico? Rev Invest Clin. 2012;64:541-5.

5. Eldin C, Mahamat A, Demar M, Abboud P, Djossou F, Raoult D. Q fever in French Guiana. Am J Trop Med Hyg. 2014;91:771-6. doi: 10.4269/ajtmh.14-0282

6. Romero-Jiménez MJ, Suárez-Lozano I, Fajardo JM, Benavente A, Menchero A, De la Iglesia A. Hepatitis aislada como forma de presentación de la fiebre Q: características clínicas y epidemiológicas en 109 pacientes. Enferm Infecc Microbiol Clin. 2003;21:193-5.

7. Epelboin L, Chesnais C, Boullé C, Drogoul AS, Raoult D, Djossou F, et al. Q fever pneumonia in French Guiana: prevalence, risk factors, and prognostic score. Clin Infect Dis. 2012;55:67-74. doi: 10.1093/cid/cis288

8. Bruguera M, Miquel R. Granulomas hepáticos. GH Continuada. 2009;8(4):191-6.

9. Chawla V, Trivedi TH, Yeolekar ME. Epidemic of leptospirosis: an ICU experience. J Assoc Pyisicians India. 2004;52:619-22.

10. Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLOS Neglected Tropical Diseases. 2015;9(9):1-19. DOI:10.1371/journal.pntd.0003898

11. Raoult D, Tissot-Dupont H, Foucault C, Gouvernet J, Fournier PE, Bernit E, et al. Q fever 1985-1998: clinical and epidemiologic features of 1383 infections. Medicine (Baltimore). 2000;79(2):109-23.

12. Suárez Ortega S, Rivero Vera J, Hemmersbach M, Artiles Campelo F, Reyes Pérez R. Betancor León P. Hepatitis colestásica grave por fiebre Q: presentación de un caso. Gastroenterol Hepatol. 2010;33(1):21-4.

13. Suárez Ortega S, Melado Sánchez P, Delgado Martínez J, Artiles Vizcaíno J, Parrilla Díaz J, Betancor León P. Incidence of anticardiolipin antibodies, parameters of hypercoagulability and venous thrombosis in the active tuberculosis. EJIM. 1995;6:161-4.

14. Raoult D. Q fever: still a mysterious disease. QJM. 2002;95:491-2.

15. Melenotte C, Million M, Audoly G, Gorse A, Dutronc H, Roland G, et al. B-cell non- Hodgkin lymphoma linked to Coxiella burnetii. Blood. 2016 Jan 7;127(1):113-21. DOI 10.1182/blood-2015-04-639617

16. Somasundaram R, Loddenkemper C, Zeitz M, Schneider T. A souvenir from the Canary Islands. Lancet. 2006;367:1116.