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Revista Mexicana de Medicina Transfusional

ISSN 2007-6509 (Print)
Órgano oficial de la Asociación Mexicana de Medicina Transfusional A.C.
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2020, Number 1

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Rev Mex Med Transfus 2020; 13 (1)

Window period for hepatitis B, NAT detection

Cortés AA, Sánchez DG, Rivera LMR, Aranda OJR, Robles RRJ, Benítez AG
Full text How to cite this article 10.35366/95495

DOI

DOI: 10.35366/95495
URL: https://dx.doi.org/10.35366/95495

Language: Spanish
References: 11
Page: 15-21
PDF size: 156.94 Kb.


Key words:

HBV, NAT, window period, TTI, hepatitis B, nucleic acid test, seroconversion, transfusion.

ABSTRACT

Among the diseases transmitted by transfusion in Mexico, 5 are mandatory for screening and detection for health risks and the costs they cause: HCV, HBV, syphilis, Chagas and HIV type 1 and 2. Within these TTD (transfusion-transmitted diseases) hepatitis defined as inflammation of liver cells, caused in most cases by viruses is the central issue in this article, three cases detected by technology of nucleic acids are exposed. One of them achieving detailed follow-up from the reactivity to NAT, seroconversion to acute stage and diagnosis by means of viral panel. The other two cases detected in the window period when donating, with subsequent seroconversion evidenced after viral panel control in laboratories of the Specialty Medical Unit of High Specialty Hospital CMNSXXI. Evidence that the implementation of nucleic acid detection technology in blood banks increases transfusion safety, by significantly reducing the residual risk of transfusing blood components found in said window period, avoiding the consequent impact on the health of people who may have been transfused with these blood components and donors when the infection was detected early.


REFERENCES

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Rev Mex Med Transfus. 2020;13