2020, Number 2
Analysis of the global research on conjugate vaccines with the BD-BiPat platform
Full text
Language: Spanish
References: 14
Page: 68-74
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ABSTRACT
The technology for the development of conjugate vaccines consist of the union of bacterial polysaccharides and a protein carrier. This procedure constitutes one of the main challenges in the world of vaccinology and therefore of the Cuban Expert Committee on Vaccines. This committee guides and discusses strategies for the development and introduction of new vaccines in Cuba. The aim of this work was to perform an analysis of the global research on conjugated vaccines with the BD-BiPat platform (Finlay Institute of Vaccines, Cuba). This platform allows access with search forms directly to the PubMed MeSH and extract data for normalization, analysis and visualization. The term used was “Vaccines, Conjugate”. The data corpus consisted of 3852 records to which metric indicators of co-occurrence and visualizations in the form of networks were applied. The study showed that it is a novel technology, which has increased rapidly worldwide. Among the most studied infectious agents associated with conjugate vaccines are Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae and Salmonella Typhi. The United States of America and the United Kingdom were the most productive countries. Results could be useful for decision-makers in scientific policy for the vaccine development, as well as introduction of vaccines in programs of immunization. Likewise, the functionalities of the BD-BiPat platform can be extended to surveillance and intelligence groups in this sector.REFERENCES
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Linares-Pérez N, Toledo-Romaní M, Casanova-González M, Paredes-Moreno B, Valdés-Balbín Y, Santana-Mederos D, et al. La nueva vacuna cubana antineumocócica, de las evidencias científicas disponibles, a la estrategia de evaluación clínica y de impacto. Rev Cubana Pediatr 2017;89(Supl 1):181-96. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/199/111.
Linares-Pérez N, Toledo-Romaní M, Santana-Mederos D, García-Fariñas A, García-Rivera D, Valdés-Balbín Y, et al. From individual to herd protection with pneumococcal vaccines: the contribution of the Cuban pneumococcal conjugate vaccine implementation strategy. Int J Infect Dis 2017;60:98-102. doi: 10.1016/j.ijid.2017.03.011.