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Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2020, Number 3

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Rev Salud Publica Nutr 2020; 19 (3)

Association between concentrations of ferritin, CRP, sTFR and HbA1c in subjects with and without DM2

Márquez IAA, González PAM

Language: Spanish
References: 32
Page: 8-18
PDF size: 371.34 Kb.


ABSTRACT

Introduction: An inflammatory component has been shown to exist in the pathogenesis of type 2 diabetes (DM2) and has been associated with elevations in serum ferritin levels. Objective: to evaluate the association between serum ferritin concentrations, CRP, soluble transferrin receptors (sTfR) and glycosylated hemoglobin (HbA1c) in subjects with and without type 2 diabetes. Material and method: Secondary study, derived from ENSANUT 2006. Concentrations of ferritin, sTFR and CRP (n=4578) were analyzed, HbA1c and ferritin (n=287) were associated, and variables such as, body mass index (BMI), age, sex, current treatment for DM2, smoking and alcohol consumption. Statistical analysis was performed with multiple logistic regression models and multiple linear regression models. An association with a value of p <0.05 was considered significant and the direction and magnitude of the association. Results: The possibility of having DM2 was associated with serum ferritin and CRP concentrations (p‹0.02). Ferritin was inversely associated with sTFR (β -0.91, p‹0.001). HbA1c was not associated with ferritin. Conclusions: In Mexicans with DM2 serum ferritin is higher than in subjects with diabetes and its variability is explained by indicators of iron status and inflammation.


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