medigraphic.com
ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2020, Number 3

Next >>

Rev Mex Patol Clin Med Lab 2020; 67 (3)

COVID-19 y drepanocitosis

Velázquez-Gómez M, Ruiz-Pérez J, Culebro-Cruz EP

Language: Spanish
References: 16
Page: 124-128
PDF size: 266.54 Kb.


ABSTRACT

Introduction: COVID-19 is an acute respiratory illness characterized by fever, dry cough, tiredness, nasal congestion, headache, anosmia, and even shortness of breath. Sickle cell disease is a hereditary condition due to the presence of hemoglobin S (HbS) which, when oxygen is low, the red blood cells are deformed causing occlusion of the microcirculation generating hyperstimulation of the upper airways and pulmonary hypertension. Objective: To know the importance of sickle cell induction in patients suspected of COVID-19 or other respiratory diseases. Material and methods: Suspicious cases compatible with COVID-19 were analyzed from April-August 2020, by hematic biometry, sickle cell induction, and blood smear, electrophoresis of hemoglobin, glucose, cholesterol, triglycerides, C-reactive protein, febrile reactions and anti-dengue Duo. Results: Of 309 patients, 225 (72.8%) were men and 84 (27.2%) were women, the mean age was 53.2 ± 8 years of age, 6 (1.94%) cases of sickle cell disease were detected (5 heterozygous and 1 homozygous) with indices normal hematological tests, confirmed by hemoglobin electrophoresis. Conclusions: Sickle cell induction and blood smear reading should be performed in all patients with or without anemia, especially those where blood oxygen levels are compromised.


REFERENCES

  1. Paho.org. [Online] 2020; [Accessed 9 September 2020] Available at: https://www.paho.org/hq/index.php?option=com_docman&view=download&category_slug=health-systems-services-sistemas-servicios-salud-5372&alias=21393-estandares-trabajo-servicios-sangre-tercera-edicion-393&Itemid=270&lang=es.

  2. Preguntas y respuestas sobre la enfermedad por coronavirus (COVID-19). [Recuperado 11 Septiembre 2020] Disponible en: https://www.who.int/es/emergencies/diseases/novel-coronavirus-2019/advice-for-public/q-a-coronaviruses#:~:text=sintomas, 2020.

  3. Herrick JB. Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Arch Inter Med. 2010; 6: 517.

  4. Galiza G, Da Silva M. Aspectos moleculares da anemia falciforme. Bras Patol Med Lab. 2003; 39: 51-66.

  5. Argüelles R. Fundamentos de Hematología. 4ª ed. Buenos Aires, Argentina: Médica Panamericana, 2009.

  6. Piel FB, Steinberg MH, Rees DC. Sickle Cell Disease. N Engl J Med 2017; 376:1561-73.

  7. Chakravorty S, Williams TN. Sickle cell disease: a neglected chronic disease of increasing global health importance. Arch Dis Child 2015; 100:48–53.

  8. National Institutes of Health. National Heart, Lung, and Blood Institute Division of Blood Diseases and Resources. The management of sickle cell disease. Fourth Edition. Bethesda, MD: NIH Publication 2015.

  9. Mesa-Cuervo JR, Cháguez-Leyva O, Hechavarría-Miyares J, Plasencia-Ternblóm A, Losada-Buchillón R, Rodríguez LR et al. Modificaciones funcionales ventilatorias en pacientes con anemia drepanocítica y antecedentes de síndrome torácico agudo. Rev Cubana Hematol Inmunol Hemoter. 2016; 18 (2).

  10. Fonseca CSV, Araújo-Melo CA, Matias de Carvalho R, Barreto-Neto J, Gonçalves Araújo J, Cipolotti R. Função pulmonar em portadores de anemia falciforme. Rev Paul Pediatr. 2017; 29 (1): 85-90.

  11. Drepanocitosis | Federación Mexicana de Enfermedades Raras. [Recuperado 11 September 2020] Disponible en: http://www.femexer.org/2613/drepanocitosis/2020.

  12. World Medical Association. Declaration of Helsinki: ethical principles for medical research involving human subjects. Edinburgh, 2015.

  13. Secretaría de Salud. Ley General de Salud de México y disposiciones complementarias. Ciudad de México, México: Editorial Porrúa 1994.

  14. OMS. Epidemiología mundial de las hemoglobinopatías e indicadores de los servicios correspondientes. [Recuperado 11 Septiembre 2020] Disponible en: https://www.who.int/bulletin/volumes/86/6/06-036673-ab/es/.

  15. Peñaloza-Espinosa, Rosenda I, Buentello-Malo, Leonor, Hernández-Maya, Arcelia, Nieva-García, Beatriz, Lisker-Yurkowitzki, Rubén, & Salamanca-Gómez, Fabio. Frecuencia de la hemoglobina S en cinco poblaciones mexicanas y su importancia en la salud pública. Salud Pública de México. 2016; 50 (4): 325-329. Recuperado en: 11 de septiembre de 2020, Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342008000400011&lng=es&tlng=es.

  16. Hernández-González E. Hematología elemental “Lo que usted necesita saber” (anemia drepanocítica). 2ª ed. Veracruz, México. 2019, pp. 70-79.




2020     |     www.medigraphic.com