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Federación Mexicana de Ginecología y Obstetricia, A.C.

2020, Number 12

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Ginecol Obstet Mex 2020; 88 (12)

Correlation of vitamin D values with those of anti-Müllerian hormone in infertile women

Garza-Garza MA, Aguilar-Melgar AE, Dávila-Garza SA, Galache-Vega P, Santos-Haliscak R

Language: Spanish
References: 14
Page: 833-838
PDF size: 185.18 Kb.


ABSTRACT

Objective: To evaluate the association between serum concentrations of 25-hydroxyvitamin D and antimullerian hormone in Mexican patients with infertility.
Materials and Methods: Retrospective, cross-sectional study of relational analysis of patients who came to consult at the IECH Fertility Center between the months of May 2019 and May 2020. The Kolmogorov-Smirnov normality test was used, with means and standard deviations (SD) for normal values; medians and interquantity ranges (IQR) for non-parametric values. To show differences between the groups the paired t-test and Mann-Whitney test were applied depending, respectively, on the normality of the data and the Spearman correlation coefficient to calculate the dependence between non-parametric variables. GraphPad Prism (v 8) was used, the value of p ‹ 0.05 was considered with statistical significance.
Results: A total of 106 files of patients diagnosed with infertility with a mean age of 35 4.97 and a median of 19.90 ng/mL (IQR 57.06) of 25-hydroxyvitamin D were analyzed. Vitamin D deficiency (less than 20 ng/mL) was not associated with antimullerian hormone values (p = 0.0525); a difference was found between vitamin D con- centrations for patients younger and older than 35 years (p = 0.0423) and a correlation between vitamin D and antimullerian hormone (Spearman’s rho: -0.210, 95%CI -0.41 to -0.005, p = 0.0495).
Conclusions: 50% of the infertile patients had vitamin D deficiency. Although the mechanism is not properly elucidated, there is a dependence on the values of 25-hydroxyvitamin D and the antimullerian hormone.


REFERENCES

  1. Christakos S, et al. Vitamin D: metabolism. Rheumatic Disease Clinics. 2012; 38 (1): 1-11. doi. 10.1016/j. rdc.2012.03.003.

  2. DeLuca HF. The vitamin D system in the regulation of calcium and phosphorus ometabolism. Nutr Rev. 1979. doi: 10.1111/j.1753-4887.1979.tb06660.x.

  3. Jellinger P, et al. American Association of Clinical Endocrinologists’ guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocrine practice. 2012; 18 (Supplement 1): 1-78. doi. 10.4158/ep.18.s1.1.

  4. Clark P, et al. High prevalence of hypovitaminosis D in Mexicans aged 14 years and older and its correlation with parathyroid hormone. Arch Osteoporos. 2015; 10: 225. doi. 10.1007/s11657-015-0225-4.

  5. Seifer DB, Maclaughlin DT. Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. Fertil Steril. 2007; 88 (3): 539-46. doi. 10.1016/j. fertnstert.2007.02.014.

  6. Jacobs MH, et al. A multicentre evaluation of the Elecsys(®) anti-Müllerian hormone immunoassay for prediction of antral follicle count. Reprod Biomed Online. 2019; 38 (5): 845-52. doi. 10.1016/j.rbmo.2018.12.041.

  7. Definitions of infertility and recurrent pregnancy loss. Fertil Steril. 2008; 90 (5 Suppl): S60. doi. 10.1016/j.fertnstert. 2008.08.065.

  8. Merhi Z, et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014; 99 (6): E1137-45. doi: 10.1210/jc.2013-4161.

  9. Drakopoulos P, et al. The effect of serum vitamin D levels on ovarian reserve markers: a prospective cross-sectional study. Human Reproduction. 2016; 32 (1): 208-14. doi. 10.1093/humrep/dew304.

  10. Lata I, et al. To Study the Vitamin D Levels in Infertile Females and Correlation of Vitamin D Deficiency with AMH Levels in Comparison to Fertile Females. J Hum Reprod Sci. 2017; 10 (2): 86-90. doi. 10.4103/jhrs.JHRS_105_16.

  11. Alavi N, et al. The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective crosssectional study. Int J Reprod Biomed (Yazd). 2020; 18 (2): 85-92. doi. 10.18502/ijrm.v18i2.6501.

  12. Mosher WD, Pratt WF. Fecundity and infertility in the United States: incidence and trends. Fertility and sterility. 1991; 56 (2): 192-3. doi. 10.1016/s0015-0282(16)53990-9.

  13. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril. 2014; 102 (2): 460-8.e3. doi. 10.1016/j.fertnstert. 2014.04.046.

  14. Pagliardini L, et al. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients. 2015; 7 (12): 9972-84. doi. 10.3390/nu7125516.




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