2001, Number 1
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ABSTRACTThe benefitial effects of inhaled racemic epinephrine in pediatric patients with bronchiolitis, has been well demonstrated in several studies. This drug is not available in our country, neither there are studies about its effects in bronchiolitis. Levogire epinephrine (aquous 1:1000) is available nationwide and its efficacy for the treatment of bronchiolitis is also well documented; besides it is more effective than racemic epinephrine and with less side effects. In order to corroborate the former, we decided to study a group of patients with bronchiolitis. Fifty patients with clinical diagnosis of bronchiolitis were studied. After diagnosis was stablished, each one received aquous epinephrine at a dose of 0.25 mg/kg of body weight, through a jet nebulizer. Clinical signs of respiratory distress were evaluated with the Downes score, before and after each dose of epinephrine. All patients received a total of three doses, administered 24 h appart. One patient had to be excluded because of the severity of symptoms, for which he had to be admitted to the emergency room. The clinical response of the remaining 49 patients was good. Statistical analysis was made with the Wilcoxon test, comparing the initial and final score on days 1, 2 and 3; and initial score on day 1 with final score on day 3. p value was ‹ 0.05.
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