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2020, Number 2

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Rev cubana med 2020; 59 (2)

Endothelial dysfunction in hypertension early stage

González RT, Savon MLM, Travieso PSM, Maurisset CY

Language: Spanish
References: 20
Page: 1-13
PDF size: 292.74 Kb.


ABSTRACT

Introduction: The arterial hypertension has a complex association with the endothelial dysfunction, and phenotypic alteration of the vascular endothelia that precedes the development of cardiovascular adverse events and it foreshadows future risk cardiovascular.
Objective: To determine the presence of endothelial dysfunction in precociously diagnosed hypertensive patients.
Methods: A transversal analytic study was conducted from March 2017 to March 2019, using data of the patients who attended to the military physical medical control at Dr. Luis Díaz Soto Military Hospital. Group A (GA) was formed by hypertensive patients recently diagnosed (up to a year) with no lesion in target organs; whereas Group B (GB) gathered the subjects with no hypertension. After establishing the informed consent, demographic, clinical variables were collected, and laboratory determinations and flow vasodilatation tests were performed.
Results: Endothelial dysfunction prevalence in Group A was 39, 0% (p=0, 021). Men (55, 0%) and the mean age 41, 7 ± 8, 6 years prevailed with no significant differences. 73, 0% of the hypertensive subjects was overweight or obese. The total high cholesterol (60, 0%) and the micro albuminuria (69, 0%) were the variables that contributed to the higher risk of endothelial dysfunction in hypertensive patients.
Conclusions: High prevalence of endothelial dysfunction was proven in recently diagnosed hypertensive patients. This endothelial dysfunction was associated to atherosclerosis risk factors as total high cholesterol and microalbuminuria.


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