medigraphic.com
ISSN 1560-4381 (Print)

2020, Number 2

<< Back Next >>

Correo Científico Médico 2020; 24 (2)

Molecular mechanisms of insulin secretion

Leyva MMÁ, Rodríguez MY, Rodríguez DR, Niño ES

Language: Spanish
References: 31
Page: 782-798
PDF size: 270.62 Kb.


ABSTRACT

Insulin is the main anabolic hormone; molecular mechanisms that regulate its synthesis and secretion were reviewed. The structural and functional features that allow the response of Langerhans islets β cells to glycemia changes, with the corresponding insulin secretion, were described. Secretagogues responsible for its secretion are mentioned and the sequence of glucose stimulated insulin secretion, which is the main one, is explained. Langerhans islets and β cells structural and functional features, that allow glycemia control, are described. The molecular mechanisms of the toxic effect on β cells, caused by prolonged hyperglycemia, are explained. Hypoglycemia triggered by some drugs and alcohol is explained.


REFERENCES

  1. Rio Bartulos C, Rogers MB, Williams TA, Gentekaki E, Brinkmann H, Cerff R, et al. Mitochondrial Glycolysis in a Major Lineage of Eukaryotes. Genome Biol Evolut. 2018[citado 28 /02/2020];10(9):2310-2325.Disponible en: https://academic.oup.com/gbe/article/10/9/2310/5061552

  2. Tokarz VL, MacDonald PE, Klip A. The cell biology of systemic insulin function. J Cell Biol.2018 [citado 19 /02/ 2020]; 217(7):2273–2289. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028526/

  3. Newsholme P, Cruzat V, Arfuso F, Keane K. Nutrient regulation of insulin secretion and action. J Endocrinol. 2014[citado 20 /02/2020];221(3):105–120.Disponible en: https://joe.bioscientifica.com/view/journals/joe/221/3/R105.xml

  4. Rosa G, Mingrone G, Manco M, V Euthine V, Gniuli D, R Calvani R, et al. Molecular mechanisms of diabetes reversibility after bariatric surgery. Intern J Obesity.2007 [citado 22/02/2020]; 31:1429–1436. Disponible en: https://www.nature.com/articles/0803630

  5. Hiriart M, Velasco M, Diaz Garcías CM, Larque C, Sánchez Soto C, Albarado Ibañez A, et al. Pancreatic Beta Cells in Metabolic Syndrome. En: Islets of Langerhans. 2daed. Suecia: Springer; 2014 [citado 26/02/2020]. Disponible en: https://link.springer.com/referenceworkentry/10.1007/978-94-007-6884-0_27-2#citeas

  6. Keller MP, Rabaglia ME, Schueler KL, Stapleton DS, Gatti DM, Vincent M, et al. Gene loci associated with insulin secretion in islets from nondiabetic mice. J Clin Invest. 2019[citado 26/02/2020];129(10):4419-4432. Disponible en: https://www.jci.org/articles/view/129143/pdf

  7. Keane K, Newsholme P. Chapter One - Metabolic Regulation of Insulin Secretion. En: The Pancreatic Beta Cell. Estados Unidos: Elsevier; 2014.[citado 15/02/2019][33 p].Disponible en: https://doi.org/10.1016/B978-0-12-800174-5.00001-6

  8. Fu Z, Gilbert ER, Liu D. Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes. Current Diabetes Rev. 2013[citado 20/02/2020]; 9(1): 25–53. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934755/

  9. Henquin JC, Nenquin M. Dynamics and regulation of insulin secretion in pancreatic islets from normal young children. PLoS ONE. 2016 [citado 20/02/2020]; 11(11). Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165961

  10. Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, et al. Synaptotagmin 4 regulates pancreatic β-cell maturation by modulating the Ca2+ sensitivity of insulin secretion vesicles. Dev Cell. 2018[citado 20/02/2020];45(3):347–361. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962294/

  11. Bowens L, Rooman I. Regulation of Pancreatic Beta-Cell Mass. Physiol Rev. 2005[citado 28 /02/2020];85(4).Disponible en: https://journals.physiology.org/doi/pdf/10.1152/physrev.00025.2004

  12. Petersen MC, Shulman G. Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018 [citado 28/02/2020];98(4):2133-2223. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977/

  13. Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro Augusto V, et al. Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli. Diabetes.2004 [citado 28/02/2020];53(4):1007-1019.Disponible en: https://diabetes.diabetesjournals.org/content/53/4/1007.short

  14. Braun M, Ramracheya R, Rorsman P. Autocrine regulation of insulin secretion. Diabet Obesity Metabol. 2012[citado 28/02/2020];14(Suppl 3):143–151.Disponible en: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1463-1326.2012.01642.x

  15. Goulley J. Role of BMP signaling and ASNA1 in β-cells.[Tesis].[Suecia]:Umea Center of Molecular Medecine, Umeå University. 2008. 66p.Disponible en: http://umu.diva-portal.org/smash/get/diva2:142067/FULLTEXT01.pdf

  16. Lieberman M, Peet A. Regulation of enzymes. En: Marks' Basic Medical Biochemistry: A Clinical Approach. 5th ed. Philadelphia: Wolters Kluwer;2018.[citado 15/05/2019].[1008].Disponible en: https://www.pdfdrive.com/marks-basic-medical-biochemistry-a-clinical-approach-5th-edition-d158491166.html

  17. Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB. Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 2008 [citado 22 /02/2020]; 295(6):1287-1297.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603555/

  18. Huopio H, Shyng SL, Otonkoski T, Nichols CG. KATP channels and insulin secretion disorders. Am J Physiol Endocrinol Metab. 2002 [citado 20/02/ 2020]; 283(2):207-216. Disponible en: https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00047.2002

  19. Boland BB, Rhodes CJ, Grimsby JS. The dynamic plasticity of insulin production in b-cells. Mol Metab.2017 [citado 21/02/2020];6(9):958-973.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605729/

  20. Llanos P, Contreras Ferrat A, Barrientos G, Valencia M, Mears D, Hidalgo C. Glucose-Dependent Insulin Secretion in Pancreatic β -Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors. PLoS ONE. 2015 [citado 26/02/2020];10(6). Disponible en: https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0129238

  21. Karschin J, Lagerpusch M, Enderle J, Eggeling B, Müller MJ, Bosy Westphal A. Endocrine Determinants of Changes in Insulin Sensitivity and Insulin Secretion during a Weight Cycle in Healthy Men. PLoS ONE. 2015[citado 27/02/2020];10(2). Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117865

  22. Van de Velde S, Wiater E, Tran M, Hwang Y, Cole PA, Montminya M. CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers. Mol Cell Biol. 2019 [citado 26/02/2020];39(17). Disponible en: https://mcb.asm.org/content/39/17/e00200-19

  23. Filippi BM, Mighiu PI, Lam TK. Is Insulin Action in the Brain Clinically Relevant? Diabetes.2012 [citado 26/02/2020];61(4):773-775. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314359/

  24. Steiner JL, Crowell KT, Lang CH. Impact of Alcohol on Glycemic Control and Insulin Action. Biomolecules. 2015 [citado26/02/2020];5(4):2223-2246. Disponible en: https://www.mdpi.com/2218-273X/5/4/2223

  25. Vihonen H, Kuisma M, Nurmi J. Hypoglycaemia without diabetes encountered by emergency medical services: a retrospective cohort study. Scand J Trauma Resusc Emerg Med.2018 [citado 27/02/2020]; 26(1):12.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796568/

  26. Martín Timón I, Cañizo Gómez FJ. Mechanisms of hypoglycemia unawareness and implications in diabetic patients. World J Diabetes. 2015 [citado 26 /02/202];6(7):912-926. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499525/

  27. Li J, Zhang N, Ye B, Ju W, Orser B, Fox J, et al. Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels. Br J Pharmacol. 2007[citado 26 /02/2020];151(4):483-493. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013967/

  28. Salehi M, Vella A, McLaughlin T, Patti ME. Hypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies. J Clin Endocrinol Metab. 2018 [citado 27/02/2020];103(8):2815-2826. Disponible en: https://academic.oup.com/jcem/article/103/8/2815/4991903

  29. Conley TE, Mohiuddin A, Naz N. Severe cotrimoxazole induced hypoglycaemia in a patient with microscopic polyangiitis. BMJ Case Rep. 2017 [citado 27/02/2020]; 2017.Disponible en: https://casereports.bmj.com/content/2017/bcr-2016-218976.

  30. Kenteu B, Noubiap JJ, Etoa MC, Azabji Kenfack M, Dehayem M, Sobngwi E. Acute glycaemic effects of co-trimoxazole at prophylactic dose in healthy adults. BMC Endocr Disord.2016 [citado 27 /02/2020]; 16(1):62. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143444/

  31. Njomatchoua AC, Tankeu AT2, Sobngw E, Mbanya JC. Glycemic efects of quinine infusion in healthy volunteers. BMC Res Notes. 2017 [citado 27/02/2020]; 10(1). Disponible en: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2744-0




2020     |     www.medigraphic.com