2021, Number 1
Gastric sarcoidosis
Roig-Marín N, Roig-Rico P, Chazarra-Pérez P, Calbo-Maiques J, Mayol-Belda MJ, Martínez-Egea A, Seguí-Ripoll JM
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Language: Spanish
References: 10
Page: 140-143
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ABSTRACT
Background: Sarcoidosis is a systemic granulomatous disease of unknown origin, characterized by noncaseating granulomas. Symptomatic gastrointestinal involvement of sarcoidosis is rare and occurs in less than 1% of cases.Clinical case: A 47-year-old female patient with asthenia, anorexia and weight loss of 9 months of evolution, accompanied in the last weeks of nausea and vomiting. The examination revealed bilateral laterocervical, axillary and inguinal adenopathies of small size, soft, non-adherent, and folliculo-nodular lesions in the lower limbs. Gastroscopy was compatible with antral-predominant pangastritis, and the pathological anatomy revealed severe chronic granulomatous gastritis compatible with gastric involvement due to sarcoidosis. Treatment was started with deflazacort at a dose of 30 mg/day, with clinical improvement at two weeks.
Conclusiones: Gastrointestinal sarcoidosis is a rare form of extrapulmonary sarcoidosis. Gastric cancer has been associated with gastric sarcoidosis. The main diagnostic role is played by histological evidence of non-caseating granulomas in the biopsy of the gastric mucosa. Medical treatment consists mainly of immunosuppressive therapy. Proton pump inhibitors can partially relieve the clinical symptoms of these patients.
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