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2020, Number 3

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Cuba y Salud 2020; 15 (3)

Approach to the dynamics of the immune response in the COVID-19 infection

Pérez CM, Pardo MD, Acosta TJR, Alonso RA

Language: Spanish
References: 39
Page: 76-82
PDF size: 310.88 Kb.


ABSTRACT

Objetivo: to characterize the peculiarities of the dynamics of the immune response during infection with COVID-19.
Development: the immune system plays a role in the pathogenesis of COVID-19, where the neutrophil infiltrate is an important event during the disease. The production of proinflammatory cytokines by abnormal activations of the signaling and dysregulation pathways in interferons are mechanisms involved in the immune response of this disease. These evidences justify the use of immunosuppressive treatments such as methylprednisolone in patients with severe symptoms. The adaptive immune response appears after two weeks of infection, although IgM is detected from the first week. The response of T lymphocytes is essential in the complete elimination of the viral infection.
Conclusions: the immune system plays an important role in the destruction of the alveolar epithelium and the development of severe symptoms of COVID-19, hence immunomodulatory treatments can benefit these patients.


REFERENCES

  1. De Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host Factors in Coronavirus Replication. En: Tripp R., Tompkins S (eds). Roles of Host Gene and Non-coding RNA Expression in Virus Infection. Current Topics in Microbiology and Immunology.: Springer, Cham [Internet] 2017 [Citado 6 de mar. de 2020]; 419: Disponible en: https://link.springer.com/chapter/10.1007%2F82_2017_25#citeas

  2. Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virology Journal [Internet]. 2019 [Citado 6 de mar. de 2020] 16:69: [aprox 22 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537279/pdf/12985_2019_Article_1182.pdf

  3. Graham RL, Donaldson EF, Baric RS. A decade after SARS: strategies for controlling emerging coronaviruses. Nat Rev Microbiol [Internet]. 2013 [Citado 15 de mar. de 2020]; 11: [aprox 12 p.]. Disponible en: https://www.nature.com/articles/nrmicro3143.pdf

  4. Čivljak R, Markotić A, Kuzman I. The third coronavirus epidemic in the third millennium: what’s next? Croat Med J [Internet]. 2020 [Citado 14 de mar de 2020]; 61: [aprox 4 p.]: Disponible en: http://www.cmj.hr/2020/61/1/32118371.htm

  5. Okada P, Buathong R, Phuygun S, Thanadachakul T, Parnmen S, Wongboot W, et al. Early transmission patterns of coronavirus disease 2019 (COVID-19) in travelers from Wuhan to Thailand, January 2020. Euro Surveill [Internet]. 2020 [Citado 7 de mar de 2020]; 25(8): [aprox 5 p.]. Disponible en: https://www.eurosurveillance.org/docserver/fulltext/eurosurveillance/25/8/eurosurv-25-8-2.pdf?expires=1583604197&id=id&ac cname=guest&checksum=FBFA59680C01EFD40ECF7189AF82B567

  6. Zhan S, Yang YY, Fu C. Public’s early response to the novel coronavirus–infected pneumonia. Emerging Microbes & Infections [Internet]. 2020 [Citado 7 de mar de 2020]; 9 [aprox 1 p.]. Disponible en: https://www.tandfonline.com/doi/pdf/10.1080/22221751.2020.1732232?needAcce ss=true

  7. Ghebreyesus TA. Alocución de apertura del Director General de la OMS en la rueda de prensa sobre la COVID-19 celebrada el 6 de marzo de 2020. [Internet]. 6 de marzo de 2020. [Citado 7 de mar de 2020]; [aprox 5 p.]. Disponible en: https://www.who.int/es/dg/speeches/detail/whodirector- general-s-opening-remarks-at-the-media-briefing-on-covid-19---6-march-2020

  8. Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol [Internet]. 2020 [Citado 21 de mar de 2020]; [aprox 1 p.]. Disponible en: http://apjai-journal.org/wp-content/ uploads/2020/02/Covid_AP-200220-0772.pdf

  9. Villegas-Chiroque M. Pandemia de COVID-19: pelea o huye. Rev Exp Mex [Internet]. 2020 [Citado 14 de mar de 2020]; 6(1): [aprox 2 p.]. Disponible en: http://rem.hrlamb.gob.pe/index.php/REM/article/view/424

  10. Martinez L. COVID-19: No existen nuevos casos confirmados en Cuba y los cuatro enfermos mantienen una evolución favorable. Cubadebate. [Internet]. 14 marzo 2020 [Citado 15 de mar de 2020]; [aprox 4 p.]. Disponible en: http://www.cubadebate.cu/noticias/2020/03/14/covid-19- no-existen-nuevos-casos-confirmados-en-cuba-y-los-cuatro-enfermos-mantienen-una-evolucion-favorable/#.Xm58SXKZI2w

  11. Redacción de Cubadebate. Cuba reporta 21 nuevos casos positivos a la COVID-19 y otra alta médica. Cubadebate [Internet]. 14 de mar 2020 [citado 2 de abr de 2020]; [aprox 5 p.]. Disponible en: http://www.cubadebate.cu/noticias/2020/04/02/cuba-reporta-21-nuevos-casospositivos- a-la-covid-19-y-una-alta-medica/#.XoaOc3KZI2w

  12. Ahmed SF, Quadeer, A.A, McKay MR. Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies. Viruses [Internet]. 2020 [Citado 15 de mar de 2020]; 12(3): [aprox 15 p.]. Disponible en: https:// www.mdpi.com/1999-4915/12/3/254/htm

  13. Kindler E, Thiel V, Weber F. Chapter Seven - Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Adv Virus Res [Internet]. 2016[Citado 22 de marzo de 2020]; 96: p. 219-243 [aprox 24 p.]. Disponible en: https://www.sciencedirect.com/science/article/ pii/S0065352716300458?via%3Dihub

  14. Tiana X, Lia C, Huanga A, Xiaa S, Lua S, Shi Z, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerging Microbes & Infections [Internet]. 2020; [Citado 15 de mar de 2020]; 9: p. 381-385 [aprox 4 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048180/pdf/TEMI_9_1729069.pdf

  15. Li G, Fan Y, Lai Y, Han T, Li Z, Zouh P, et al. Coronavirus infections and immune responses. J Med Virol [Internet]. 2020 [Citado 20 de mar de 2020]; 92: p. 424-32: [aprox 8 p.]. Disponible en: https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25685

  16. Lacagnina M, Watkins L, Grace P. Toll-like receptors and their role in persistent pain. Pharmacol Ther [Internet]. 2018 [Citado 20 de mar de 2020]; 184: p. 145-184 [aprox 39 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858962/

  17. Arenas-Padilla M, Mata-Haro V. Regulation of TLR signaling pathways by microRNAs: implications in inflammatory diseases. Cent Eur J Immunol [Internet]. 2018 [Citado 20 de mar de 2020]; 43(4): p 482-489 [aprox 8 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC6384427/

  18. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019. Pneumonia in Wuhan, China. JAMA Intern Med [Internet]. 2020 [Citado 20 de mar de 2020]; [aprox 10 p.]. Disponible en: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2763184

  19. Conti P, Ronconi G, Caraffa A, Gallenga C, Ross R, Frydas I, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents [Internet]. 2020 [Citado 14 de mar de 2020]; 34(2): p.1 [aprox 1 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32171193

  20. She J, Jiang J, Ye L, Hu L, Bai C, Song Y. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med [Internet]. 2020 [Citado 15 de mar de 2020]; 9: p. 19. [aprox 7 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC7033263/

  21. Fung T, Liu D. Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol [Internet]. 2019 [Citado 22 de mar de 2020]; 73: p. 529- 557 [aprox 31 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/31226023

  22. Crow M, Ronnblom L. Type I interferons in host defence and inflammatory diseases. Lupus SciMed [Internet]. 2019 [Citado 21 de mar de 2020]; 6(1): p. e000336 [aprox 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/31205729

  23. Sin-Yee F, Kit-San Y, Zi-Wei Y, Chi-Ping C, Dong-Yan J. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerging Microbes & Infections [Internet]. 2020 [Citado 21 de mar de 2020]; 9: p. 558- 570 [aprox 13 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103735/pdf/TEMI_9_1736644.pdf

  24. Juanez Sanchez W, del Sol González Y. Biocubafarma garantizará producción de los 22 medicamentos para el tratamiento del Covid-19. Granma. [Internet]. 13 mar 2020 [Citado 21 de mar de 2020]; Disponible en: http://www.granma.cu/cuba-covid-19/2020-03-13/biocubafarmay- la-covid-19-tenemos-el-interferon-que-equivaldria-a-tratar-en-cuba-a-todos-los-infectados-en-china

  25. Nelemans T, Kikkert M. Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections. Viruses [Internet]. 2019 [Citado 21 de mar de 2020]; 11(10): p.E961 [aprox 23 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832425/pdf/ viruses-11-00961.pdf

  26. Reese S, Dalamani G, Kaspers B. The avian lung-associated immune system: a review. Vet Res [Internet]. 2006 [Citado 22 de mar de 2020]; 37(3): p. 311-324 [aprox 14 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/16611550

  27. Calzas C, Chevalier C. Innovative Mucosal Vaccine Formulations Against Influenza A Virus Infections. Front Immunol [Internet]. 2019 [Citado 21 de mar de 2020]; 10: p. 1605 [aprox 21 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650573/

  28. Worbs T, Hammerschmidt S, Förster R. Dendritic cell migration in health and disease. Nat Rev Immunol [Internet]. 2017 [Citado 22 de marzo de 2020]; 17(1): p. 30-48 [aprox 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27890914

  29. Justiz Vaillant A, Qurie A. Interleukin. EnStatPearls.. Treasure Island (FL): StatPearls Publishing; 2020. [Citado 21 de mar de 2020]; [aprox 19 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK499840/

  30. Chiavolini D, Rangel-Moreno J, Berg G, Christian K, Oliveira-Nascimento L, al e. Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia. PLoSOne [Internet]. 2010 [Citado 21 de mar de 2020]; 5(6): p. e11156 [aprox 13 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/20585390

  31. Qin C, Zhou L, Hu Z, Zhan S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clinical Infectious Diseases [Internet]. 2020 [Citado 20 de Marzo de 2020]; p.ciaa248 [aprox 24 p.]. Disponible en: https://academic.oup.com/cid/ advance-article/doi/10.1093/cid/ciaa248/5803306

  32. Giacalone V, Margaroli C, Mall M, Tirouvanziam R. Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease. Int J Mol Sci [Internet]. 2020 [Citado 22 de mar de 2020]; 21(3): p. pii: E851 [aprox 21 p.]. Disponible en: https:// www.ncbi.nlm.nih.gov/pubmed/32013006

  33. Bruns B, Hönle T, Kellermann P, Ayala A, Perl M. Divergent Effects of Neutrophils on Fas-Induced Pulmonary Inflammation, Apoptosis, and Lung Damage. Shock [Internet]. 2017 [Citado 22 de mar de 2020]; 47(2): p. 225-235 [aprox 11 p.]. Disponible en: https://www.ncbi.nlm.nih. gov/pubmed/27405068

  34. Camp J, Jonsson C. Camp JV1, Jonsson CB2. Front Immunol [Internet]. 2017 [Citado 22 de mar de 2020]; 8: p. 550 [aprox 17 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28553293

  35. Rudd J, Pulavendran S, Ashar H, Ritchey J, Snider T, Malayer J. Neutrophils Induce a Novel Chemokine Receptors Repertoire During Influenza Pneumonia. Front Cell Infect Microbiol [Internet]. 2019 [Citado 22 de marzo de 2020]; 9: p. 108 [aprox 12 p.]. Disponible en: https://www. ncbi.nlm.nih.gov/pubmed/31041196

  36. Yao X.Y., Li T.Y., He Z.C., Ping Y.F., Liu H.W., Yu S.C., Mou H.M, et al. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li XueZaZhi [Internet]. 2020 [Citado 27 de marzo de 2020]; 49(0): p. E009 [aprox 2 p.]. Disponible en: https://www. ncbi.nlm.nih.gov/pubmed/32172546

  37. Choudhry H, Bakhrebah MA, Abdulaal WH, Zamzami MA, Baothman OA, Hassan MA, et al. Middle East respiratory syndrome: pathogenesis and therapeutic developments. Future Virol [Internet]. 2019 [Citado 2020 de mar de 2020]; 14(4): p. 237-246: [aprox 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080179/

  38. Channappanavar R, Perlman S. Evaluation of Activation and Inflammatory Activity of Myeloid Cells During Pathogenic Human Coronavirus Infection. En Vijay R, editor. MERS Coronavirus. Methods in Molecular Biology.: Humana, New York, NY [Internet]. 2020 [Citado 27 de mar de 2020]; p 2099: Disponible en: https://link.springer.com/protocol/10.1007%2F978-1-0716-0211-9_15

  39. Fahmia M, Kubotab Y, Ito M. Nonstructural proteins NS7b and NS8 are likely to be phylogenetically associated with evolution of 2019-nCoV. Infections, Genetic and Evolutions [Internet]. 2020 [Citado 21 de marzo de 2020]; 81 [aprox 5 p.]. Disponible en: https://www.sciencedirect. com/science/article/pii/S1567134820301039?via%3Dihub




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