Cirugía y Cirujanos

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>Journals >Cirugía y Cirujanos >Year 2002, Issue 4

Flores-Álvarez E, Gómez-Acosta F, Flores-Álvarez AC, Gómez-Cruz O, Barroso-Bravo S
Diagnosis and treatment difficulties in parathyroid cancer. A case report
Cir Cir 2002; 70 (4)

Language: Español
References: 15
Page: 275-278
PDF: 299.91 Kb.

Full text


Introduction: Carcinoma of the parathyroid gland is extremely rare; it represents 0.5_3% of cases of primary hyperparathyroidism. It is functionally active and early clinical behavior is similar to that of parathyroid benign neoplasias. Diagnosis and treatment represent a true challenge for the surgeon. Case presentation: A 28 year-old woman with history of tumor in right malar region and bone pain in extremities since 1995 was treated with tumor resection on two occasions, both surgical specimens with histopathologic features of reparative granuloma of giant cells. We detected multiple bone disease, hypercalcemia and high levels of alkaline fosfatasa. MIBI radionuclide scanning showed functioning tumor located in right thyroid lobe. We performed surgical exploration of neck in August 1998 with operative features of tumor of right superior parathyroid gland; we resected the gland, frozen section indicating parathyroid adenoma. Serum calcium decreased to second day after surgery. Complete histopathologic study of surgical specimen revealed parathyroid carcinoma. Abnormal uptake in neck on radionuclide scanning and elevation of calcium and parathyroid hormone levels led to new surgical explorations with total resection of thyroid and parathyroid glands and cervical lymphatic tissue; however, we have not documented malignant activity in the histologic study of surgical specimens.

Key words: , Parathyroid carcinoma, Hyperparathyroidism, Parathyroid hormone.


  1. Shortell CK, Andrus CH, Phillips CE, Schwartz SI. Carcinoma of the parathyroid gland: a 30-year experience. Surgery 1991;110:704-708.

  2. Conh K, Silverman M, Corrado J, Sedgewick C. Parathyroid carcinoma: the Lahey Clinic experience. Surgery 1985;98:1095-1100.

  3. Levin KE, Galante M, Clark OH. Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcemia. Surgery 1987;101:649-659.

  4. Favia G, Lumachi F, Polistina F, D’Amico DF. Parathyroid carcinoma: sixteen new cases and suggestions for correct management. World J Surg 1998;22:1225-1230.

  5. Vazquez-Quintana E. Parathyroid carcinoma: Diagnosis and management. Am Surg 1997;63:954-957.

  6. Wynne AG, Van Heerden J, Carney JA, Fitzpatrick LA. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine 1992;71:197-204.

  7. Anderson BJ, Samaan NA, Vassilopoulou-Sellil, Ordónez NG, Hickey RC. Parathyroid carcinoma: features and difficulties in diagnosis and management. Surgery 1983;94:906-914.

  8. Trigonis C, Cedermark B, Willems J, Hamberger B, Granberg PO. Parathyroid carcinoma–problems in diagnosis and treatment. Clin Oncol 1984;10:10-19.

  9. Chew-Wong A, Herrera MF, Jiménez ED, Gamboa DA, Richaud PY, Bezaury P, Reza AA, Correa RR, Rull JA. Cuatro casos de cáncer de paratiroides. Rev Invest Clin 1998;50:239-244.

  10. Sandelin K, Thompson NW, Bondeson L. Metastatic parathyroid carcinoma: dilemmas in management. Surgery 1991;110:978-988.

  11. Calandra DB, Chejfec G, Foy BK, Lawrence AM, Paloyan E. Parathyroid carcinoma: biochemical and pathologic response to DTIC. Surgery 1984;96:1132-1137.

  12. Fujimoto Y, Obara T, Ito Y, Kodama T, Nobori M, Ebihara S. Localization and resection of metastatic parathyroid carcinoma. World J Surg 1986;10:539-544.

  13. Flye MW, Brennan MF. Surgical resection of metastatic parathyroid carcinoma. Ann Surg 1981;193:425-435.

  14. Shane E, Bilezikian JP. Parathyroid carcinoma: a review of 62 patients. Endocrin Rev 1982;3:218-226.

  15. Cordeiro AC, Fabio LMM, Kulcsar MAV, Dellanegra LA, Tavares MR, Michaluart P, Ferraz AR. Parathyroid carcinoma. Am J Surg 1998; 175:52-55.

>Journals >Cirugía y Cirujanos >Year 2002, Issue 4

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