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>Journals >Medicina Crítica >Year 2009, Issue 3


Montoya GC, Hernández LA, Poblano MM, Olvera GC, Aguirre SJ, Granillo JF
Antiinflammatory effect of the cystatins in sepsis
Rev Asoc Mex Med Crit y Ter Int 2009; 23 (3)

Language: Español
References: 41
Page: 130-141
PDF: 173.76 Kb.


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ABSTRACT

Statins has a well known pleiotrophic effect as antiinflammatory, immunomodulators. It has been proposed as a therapeutic tool in septical patients. Purpose:To investigate posible statins therapeutic uses in the induced sepsis inflammatory process. Methods: This was a prospective, long term and experimental design study. Results: Prospective analysis of 40 patients was due, they were divided in two randomized groups. The control group was under 80 mg of simvastatin medication along 14 days. Measures of inflammatory markers: globular sedimentation velocity (GSV), C-reactive protein (C-RP), Anti thrombin III) were performed at beginning of trial and 5, 10 and 14 day. We observed decreased levels of GSV 19 (14-23), 36 (27-50) (p ‹ 0.01). C-RP 6 (4-9), 13 (9-18), (p ‹ 0.01) and increased levels of antithrombin III 57 (49-65), 36 (29-49) (p ‹ 0.01) since fifth day. Mechanical ventilation days rated on 10 (2-12), 16 (4-18) (p ‹ 0.04). Long stay on Critical Care Unit 15 (14-16), 22 (18-26), (p ‹ 0.01). Conclusion: This study demonstrate that statins are eable to decrease the systemic inflammatory response and also showns reduce the mechanical ventilation time rates and so on with the patient long stay.


Key words: Statin, sepsis.


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