>Revista de Hematología
>Year 2014, Issue 4
Jaime-Pérez JC, Esparza-Sandoval AC, Vázquez-Mellado-De Larracoechea A, López-Serna N, Álvarez-Cantú R, Vázquez-Garza E, Gómez-Almaguer D
Micrometric determination of the most frequent leukemic blasts’ size
Rev Hematol Mex 2014; 15 (4)
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Background: The morphology of malignant cells that proliferate in the
different leukemias, including their size, is very heterogeneous; there is
scarce specific information regarding the size of these cells, which can
be of relevance to explain some clinical characteristics, like development
of hyperviscosity syndrome and thrombotic events.
Objective: To determine the size of leukemic blasts in the most frequent
Material and method: An ambispective, observational study was done
in which were stained with Wright’s stain marrow smears of patients
treated at the Hematology Service of the University Hospital Dr. Jose
Eleuterio Gonzalez, Autonomous University of Nuevo Leon, Mexico,
diagnosed with acute lymphoblastic leukemia, acute myeloblastic
leukemia and chronic myelogenous leukemia in blastic phase. Lineage
was established by flow cytometry. Clinical stages included diagnosis,
induction therapy and relapse. Those with the most representative morphologic
characteristics of each acute leukemia subtype were selected
for micrometry measurement. Data were analyzed with descriptive
statistics, obtaining median and range; size was compared with those
found in the literature.
Results: Leukemic blasts of 186 patients were studied; 111 with acute
lymphoblastic leukemia, 55 with acute myeloblastic leukemia and 20
with chronic myelogenous leukemia in blastic phase. The medians and
ranges of the cells size were: 11.3 µ (4.5-17.2), 11.2 µ (8.3-15.7) and
11.7 µ (6.6-15.0), respectively.
Conclusion: Despite the different cell origin and clinical stage of the
acute leukemias, the median size and its range was remarkably similar
among the studied patients.
||blasts, micrometry, lymphoblasts, myeloblasts, blastic crisis.
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>Revista de Hematología
>Year 2014, Issue 4