2005, Number 4
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ABSTRACTFor most of the Clinical Laboratory and Blood Bank professionals it is quite common to receive comments in order to explain a lab result that seems not to be in accordance with the patient’s condition. A frequent case, for instance, is related to the interpretation of Hepatitis B immunological profile, where it should be emphasized that this diagnosis must be done through the utilization of several contributory tests. In consequence, it is impossible to establish the clinical condition of the patient or the integral diagnosis with a single determination. In this document, important issues related to the viral structure of recently reported and understood mutant strains are discussed, including the natural history of acute and chronic Hepatitis B, the sequential appearance in blood of viral antigens and related capsid and core antibodies and their clinical relevance, plus the characteristics of immunological tests and possible causes for false positive and negative results. Finally, some recommendations are expressed in order to support clinical correlation with the etiological and psychopathological diagnosis of Hepatitis B.
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