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>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2009, Issue 2

Halabe-Cherem J, Hamui-Sutton A, Cohen-Cohen S, Sacal-Dumani E, Shuchleib-Cung A, Nellen-Hummel H, Rábago-Arredondo J
Recidivate Pericardial Effusion Due to Familiar Mediterranean Fever
Rev Med Inst Mex Seguro Soc 2009; 47 (2)

Language: Español
References: 16
Page: 211-214
PDF: 139.82 Kb.

Full text


Pericarditis is usually a complication of viral or bacterial infection. In addition, it can be associated to systemic diseases such as autoimmune disorders, rheumatic fever, cancer, tuberculosis and AIDS. It can also be related to familial Mediterranean fever, an autosomic recessive inflammatory disease, characterized by fever, abdominal pain, and pleuritis mainly seen in persons from the Mediterranean area. In this study, we described the evolution and treatment response to colchicine in three patients with pericarditis associated to familial Mediterranean fever. Two of the patients had a pericardiectomy showing in their biopsy nonspecified inflammatory changes. Later their diagnosis were confirmed by genetic markers, echocardiogram and EKG. They were treated with antiviral and antibiotics without any improvement; subsequently they had good results with colchicine.

Key words: pericarditis, familial Mediterranean fever, pericardiectomy, colchicine.


  1. Cherem JH, Hummel HN, Padilla GF. Familial Mediterranean fever in Mexico City: 10-year follow-up. Arch Intern Med 1994;154(12):1411-1414.

  2. International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997;90(4):797-807

  3. Samuels J, Aksentijevich I, Torosyan Y, Centola M, Deng Z, Sood R, Kastner DL. Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine 1998;77(4):268.297.

  4. French FMF Consortium. A candidate gene for familial Mediterranean fever. The French FMF Consortium. Nat Genet 1997;17(1):25-31.

  5. Centola M, Wood G, Frucht DM, Galon J, Aringer M, Farrell C, et al. The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood 2000; 95(10): 3223-3231.

  6. Richards N, Schaner P, Diaz A, Stuckey J, Shelden E, Wadhwa A, et al. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. J Biol Chem 2001;276 (42):39320-39329.

  7. Tunca M, Ben-Chetrit E. Familial Mediterranean fever in 2003. Pathogenesis and management. Clin Exp Rheumatol 2003;21(4 Suppl 30):S49-S52.

  8. Aksentijevich I, Torosyan Y, Samuels J, Centola M, Pras E, Chae JJ, et al. Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population. Am J Hum Gen 1999;64(4):949-962.

  9. Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet 1998;351(9103):659- 664. 10. Cherem JH, Rábago J. Abdomen agudo no quirúrgico. Rev Invest Clin 2007;59(3):212-218.

  10. Majeed HA, Rawashdeh M, el-Shanti H, Qubain H, Khuri-Bulos N, Shahin HM. Familial Mediterranean fever in children: the expanded clinical profile. QJM 1999;92(6):309-318.

  11. Meiorin SM, Espada G, Rosé CD. Enfermedades febriles periódicas en pediatría. Arch Arg Pediatr 2006;104(1):30-38.

  12. Halabe J, Lifshitz A, López-Bárcena J, Ramiro H. El internista. Segunda edición. México: Nieto Editores; 2003.

  13. Lange U, Schumann C, Schmidt KL. Current aspects of colchicine therapy: classical indications and new therapeutic uses. Eur J Med Res 2001;6(4):150-160.

  14. Ben-Chetrit E, Levy M. Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum 1991;20(4):241-246.

  15. Kallinich T, Haffner D, Niehues T, Huss K, Lainka E, Neudorf U, et al. Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement. Pediatrics 2007;119(2):e474-e483.

>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2009, Issue 2

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