>Revista Médica del Instituto Mexicano del Seguro Social
>Year 2018, Issue 4
Chin-Chan M, Maldonado-Velázquez MG, Mex-Álvarez R, Garma-Quen PM, Cobos-Puc L
Amyloid-degrading enzymes in Alzheimer´s disease: from molecules to genetic therapy
Rev Med Inst Mex Seguro Soc 2018; 56 (4)
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Alzheimer’s disease (AD) is the main form of dementia
in elderly population worldwide. By 2010 it was
estimated that 35.6 million of people were living with
this disease, and it was projected that this figure will
triple by the year 2050. According to amyloid
hypothesis, production and aggregation of amyloid
beta (A-beta) peptide is the initial step in AD
development. A-beta peptide is generated through
proteolytic processing of amyloid precursor protein
(APP); whereas its degradation depends on the action
of a group of proteins collectively known as amyloiddegrading
enzymes (ADE), which are reduced during
aging and particularly in AD. Genetic therapy consists
in the restoration of the genetic expression of a
deficient protein to treat a disease. Brain restoration or
overexpression of ADE reduces the levels and
aggregates of A-beta, and improves learning and
memory in animal models of AD. In this review we will
describe the role of ADE in the regulation of A-beta
levels, as well as its potential use in genetic therapy
||Alzheimer Disease, Plaque, Amyloid, Genetic Therapy.
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>Revista Médica del Instituto Mexicano del Seguro Social
>Year 2018, Issue 4