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TIP Revista Especializada en Ciencias Químico-Biológicas

2022, Número 1

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TIP Rev Esp Cienc Quim Biol 2022; 25 (1)


PTP-PEST: Vías de señalización y su importancia como blanco terapéutico en cáncer

Manzanita-Quintero K, Lee-Rivera I, López E, López-Colomé AM

Idioma: Español
Referencias bibliográficas: 76
Paginas: 1-13
Archivo PDF: 505.63 Kb.


RESUMEN

La fosfatasa de tirosina PTP-PEST, también llamada PTPN12, es una proteína que se expresa de forma ubicua, y se regula por fosforilación en los residuos de serina y treonina. El gen PTPN12, en humanos, se localiza en el cromosoma 7q11.23. La proteína codificada está formada por una región N-terminal, seguida de un dominio catalítico de fosfatasa de tirosina (PTP, por sus siglas en inglés) y una cola C-terminal que contiene secuencias ricas en prolina, ácido glutámico, serina y treonina (PEST), así como, una secuencia NPLH (asparagina, prolina, leucina, histidina) que es un sitio de anclaje para las proteínas involucradas en la transducción de señales.
La PTP-PEST regula procesos fisiológicos como la migración celular, la respuesta inmune, y la actividad neuronal, a través de la desfosforilación de múltiples sustratos entre los que se cuentan proteínas adaptadoras del citoesqueleto como la paxilina, y otras involucradas en diferentes vías de señalización, algunas de las cuales aún no han sido completamente elucidadas.
Se ha demostrado la alteración de la PTP-PEST en diferentes enfermedades como el cáncer, por lo que se ha estudiado como un posible blanco terapéutico. Esta revisión se enfoca en la clasificación, estructura y el papel tanto fisiológico como patológico de la PTP-PEST.


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