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>Revistas >El Residente >Año 2009, No. 3


A Rivas-Caicedo, E García-Zepeda
Características e implicaciones terapéuticas de las células dendríticas
Residente 2009; 4 (3)

Idioma: Español
Referencias bibliográficas: 50
Paginas: 97-104
Archivo PDF: 241.00 Kb.


Texto completo




RESUMEN

La capacidad de las células dendríticas (CDs) para entrar a los ganglios linfáticos, encontrarse con los linfocitos T y presentarles antígenos para conducirlos a un estado de activación o tolerancia, hace que estas células presentadoras de antígeno (APC por sus siglas en inglés) sean las directoras de la respuesta inmune. El fenotipo y la función de las CDs varía ampliamente; y así como intervienen en la selección tímica, participan también en la secreción de citocinas específicas en el sitio de inflamación. La plasticidad que poseen estas células ha hecho difícil su clasificación, sin embargo, se han determinado marcadores que permiten identificar parcialmente los diferentes grupos de CDs, haciendo posible establecer algunas de sus características como APC, evidenciar sus capacidades de migración y analizar su papel como activadoras o inductoras de tolerancia de los linfocitos T. Las investigaciones realizadas en esta área han permitido vislumbrar a las CDs como una excelente herramienta en terapias contra el cáncer o en tratamientos para disminuir el rechazo de trasplantes. Dichos estudios se encuentran encaminados a explotar al máximo las funciones de las CDs en la clínica, quedando un amplio campo por explorar.


Palabras clave: Células dendríticas, quimiocinas, inmunoterapia, linfocitos T, tolerancia.


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>Revistas >El Residente >Año2009, No. 3
 

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