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>Revistas >Revista Médica del Instituto Mexicano del Seguro Social >Año 2013, No. 1


García-Elorriaga G, Mendoza-Aguilar M, del Rey-Pineda G, González-Bonilla C
Polimorfismos genéticos del factor de necrosis tumoral y la linfotoxina α en diabetes tipo 2
Rev Med Inst Mex Seguro Soc 2013; 51 (1)

Idioma: Inglés
Referencias bibliográficas: 32
Paginas: 42-49
Archivo PDF: 195.40 Kb.

[Texto completo - PDF]

RESUMEN

Objetivo: investigar la frecuencia de variantes polimórficas con el cambio de una sola base identificadas en los genes del tumor necrosis factor (TNF) (-308 gamma/alfa) y de la linfotoxina α (LTA) (+ 252 G/A) en pacientes con diabetes tipo 2.
Métodos: se llevó a cabo un estudio prospectivo en una población mestizo-mexicana de 51 pacientes con DT2 y 48 sujetos sanos. Se tomó una muestra de sangre periférica de cada individuo para la identificación de los genotipos polimórficos mediante la prueba de reacción en cadena de la polimerasa.
Resultados: la distribución de genotipos en los pacientes con diabetes tipo 2 fue la siguiente: TNFA homocigoto 0%; TNFG/A heterocigoto 20% y TNFG homocigoto 80%.
Conclusiones: se encontró mayor frecuencia del genotipo TNF -308 G/A, con una diferencia significativa (p = 0.012). Los sujetos sanos tuvieron mayor frecuencia (p = 0.034) del genotipo de TNF-308G/G si se comparan con el grupo de pacientes.


Palabras clave: diabetes mellitus tipo 2, alelos, genotipos, polimorfismos de una sola base, factores de necrosis tumoral.


REFERENCIAS

  1. Sánchez-Castillo C, Velázquez-Monroy O, Lara-Esqueda A, Berber A, Sepúlveda J, Tapia-Coyer R, et al. Diabetes and hypertension increases in a society with abdominal obesity: results of the Mexican National Health Survey 2000. Public Health Nutr. 2005;8(1):53-60.

  2. Villalpando S, de la Cruz V, Rojas R, Shamah-Levy T, Ávila M, Gaona B, et al. Prevalence and distribution of type 2 diabetes mellitus in Mexican adult population. A probabilistic survey. Salud Pública Mex. 2010;52 Suppl 1:S19-26.

  3. Kubaszek A, Pihlajamaki J, Komarovski V, Lindi V, Lindstrom J, Eriksson J, et al. Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes. 2003;52(7):1872-6. Disponible en http://diabetes. diabetesjournals.org/cgi/pmidlookup?view=long&p mid=12829659

  4. Li H, Groop L, Nilsson A, Weng J, Tuomi T. A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin- deficient phenotype in patients with type 2 diabetes. J Clin Endocrinol Metab. 2003;88(6): 2767-74. Disponible en http://jcem.endojournals.org/ content/88/6/2767.long

  5. Liu HL, Lin YG, Wu J, Sun H, Gong ZC, Hu PC, et al. lmpact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes. Eur J Clin Pharmacol. 2008;64(7):663-71.

  6. Kankova K, Marova I, Jansen EH, Vasku A, Jurajda M, Vacha J. Polymorphism Nco1 in tumor necrosis factor B is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects. Diabetes Metab. 2002;28(3):231-7.

  7. Kankova K, Muzik J, Karaskova J, Beranek M, Hajek D, Znojil V, el al. Duration of non-insulin dependent diabetes mellitus and the TNF-beta NCo1 genotype as predictive factors in proliferative retinopathy. Ophthalmologica. 2001;215(4):294-8.

  8. Vendrell J, Fernández-Real JM, Gutiérrez C, Zamora A, et al. A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients. Atherosclerosis. 2003;167(2):257-64.

  9. Heijmans BT, Westendorp RG, Droog S, Kluft C, Knook DL, Slagboom PE. Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort. Genes lmmun. 2002;3(4):225-8.

  10. Shiau MY, Wu CY, Huang CN, Hu SW, Lin SJ, Chang YH. TNF-alpha polymorphisms and type 2 diabetes mellitus in Taiwanese patients. Tissue Antigens. 2003;61 (5):393-7.

  11. Furuta M, Yano Y, lto K, Gabazza EC, Katsuki A, Tanaka T et al. Relationship of the tumor necrosis factor-alpha -308 A/G promoter polymorphism with insulin sensitivity and abdominal fat distribution in Japanese patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2002;56(29):141-5.

  12. lshii T, Hirose H, Saito I, Nishikai K, Maruyama H, Saruta T. Tumor necrosis factor alpha gene G- 308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men. Metabolism. 2000;49(12):1616-8.

  13. Lee SC, Pu YB, Thomas GN, Lee ZS, Tomlinson B, Cockram CS, et al. Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome. Metabolism. 2000;49(8): 1021-4.

  14. Rasmussen SK, Urhammer SA, Jensen JN, Hansen T, Borch-Johnsen K, Pedersen O. The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians. J Clin Endocrinol Metab. 2000;85(4):1731-4.

  15. Hoffstedt J, Eriksson P, Hellstrom L, Rossner S, Ryden M, Arner P. Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men. Diabetologia. 2000;43(1):117-20.

  16. Hayakawa T, Nagai Y, Taniguchi M, Yamashita H, Takamura T, Abe T, et al. Tumor necrosis factor-beta gene Ncol polymorphism decreases insulin resistance in Japanese men. Metabolism. 2000;49 (11):1506-9.

  17. Dandona P, Aljada A, Bandyopadhyay A. lnflammation: the link between insulin resistance, obesity and diabetes. Trends lmmunol. 2004;25(1):4-7.

  18. Pickup JC, Crook MA. ls type II diabetes mellitus a disease of the innate immune system? Diabetologia. 1998;41(10):1241-8.

  19. Plomgaard P, Nielsen AR, Fischer CP, Mortensen OH, Broholm C, Penkowa M, et al. Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes. Diabetologia. 2007;50(12):2562-71.

  20. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87-91.

  21. Yang J, Park Y, Zhang H, Xu X, Laine GA, Dellsperger KC, et al. Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2009;296(6):H1850-8. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716110/

  22. Norma oficial mexicana NOM-003-SSA2-19931993, para la disposición de sangre humana y sus componentes con fines terapéuticos.. Diario Oficial de la Federación del 18 de julio de 1994.

  23. Majetschak M, Flohe S, Obertacke U, Schröder J, Staubach K, Nast-Kolb D, et al. Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Ann Surg. 1999;230(2):207-14. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420863/

  24. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 1993;15 (3):532-7.

  25. Roberts AK, Monzón-Bordonaba F, Van Deerlin PG, Holder J, Macones GA, Morgan MA, et al. Association of polymorphism within the prometer of the tumor necrosis factor alpha gene with increased risk of preterm premature rupture of the fetal membranes. Am J Obstet Gynecol. 1999;180(5): 1297-302.

  26. Stuber F, Petersen M, Bokelmann F, Schade U. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor- alpha concentrations and outcome of patients with severe sepsis. Crit Care Med. 1996;24(3): 381-4.

  27. Dell BR, Holleran S, Ramakrishnan R. Sample size determination. lLAR J. 2002;43(4):207-13. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275906/

  28. Feng RN, Zhao C, Sun Ch, Li Y. Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. PLoS One. 2011;6(4):e18480. Disponible en http://192.168.23.109:15871/cgi-bin/blockpage.cgi?ws -session=3310600585

  29. Koch M, Rett K, Volk A, Maerker E, Haist K, Weisser M, et al. The tumor necrosis factor alpha -238 G -->A and -308 G -->A prometer polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of type II diabetic patients. Diabetologia. 2000;43(2):181-4.

  30. Wybranska I, Malczewska-Malec M, Niedbal S, Naskalski JW, Dembinska-Kiec A. The TNF-alpha gene Nco1 polymorphism at position -308 of the prometer influences insulin resistance, and increases serum triglycerides after postprandial lipaemia in familiar obesity. Clin Chem Lab Med. 2003;41 (4): 501-10.

  31. Santos MJ, Patiño GA, Ángel BB, Martinez HJA, Pérez BF, Villarroel BAC, et al. Asociación entre polimorfismos de la región promotora del gen del factor de necrosis tumoral alfa (TNF-alfa) con obesidad y diabetes en mujeres chilenas [Internet]. Rev Med Chil. 2006;134(9):1099-106.Disponible en http://www.scielo.cl/scielo.php?pid= S0034-98872006000900003&script=sci_arttext

  32. Boraska V, Rayner KA, Groves CJ, Frayling TM, Diakite M, Rockett KA, et al. Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. BMC Med Genet. 2010;11:69.



>Revistas >Revista Médica del Instituto Mexicano del Seguro Social >Año2013, No. 1
 

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