Häubi SC, Moreno-Santillán A, de León-Ponce MD, Briones-Vega CG, Meneses-Calderón J, Orenday-Aréchiga ME, Torres-Pérez J, Briones-Garduño JC

Language: Spanish
References: 8
Page: 240-244
PDF size: 93.77 Kb.

ABSTRACT

Human life is only possible within a narrow range of pH. Consequently, the body has different and complex mechanisms to maintain this balance. In normal circumstances, metabolic processes yield a number of acid by-products, reflecting a natural trend in pH towards acidity. However, blood pH is kept within physiological range because concentrations of hydrogen ions in both the extra- and intracellular compartments are closely controlled by the body, since very slight changes may lead to cell dysfunction. In order to maintain pH within normal ranges and avoid cell damage, hydrogen ions move across the intra and extracellular compartments. Acid-base disturbances are controlled by different buffer systems, described by Henderson and Hasselbalch using bicarbonate and carbon dioxide as independent variables. The acid-base model described by Stewart proposes that ion concentration is determined by the of laws chemistry acting upon independent variables, such as strong ion difference, carbon dioxide partial pressure, and weak anions. This paper describes important features of both methods, in order to set the basis for future research in this field.

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