Troyo BP

Language: Spanish
References: 5
Page: 146-149
PDF size: 52.21 Kb.

ABSTRACT

Chronic systemic hypertension leads to structural and functional changes in the left ventricular myocardium through external and internal stimuli, altering the molecular structure of some peptides that influence hypertrophy and remodeling development. Genetic information evokes different responses in the cardiac myocyte, altering its morphology, metabolism, protein synthesis and the bioavailability of some hormonal receptors, promoting compensatory hypertrophy or apoptosis. In response to hemodynamic stress, the myocardial cell sensitizes and liberates angiotensin II (ATII) in an endogenous fashion and makes AT₁ receptors to join this hormone tightly, perpetuating its deleterious effects. AT₁ selective blockade prevent molecular and physiological damage lowering ATII bioavailability, down-regulating its production.

REFERENCES

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