Alcocer MJL, Domínguez CLG

Language: Spanish
References: 3
Page: 381-383
PDF size: 197.46 Kb.

ABSTRACT

Introduction: primary vasculitis of the central nervous system (PVCNS) is rare, with heterogeneous clinical presentation. Case report: 35-years-old female with seven days with headache, without improvement with analgesics, adding vomiting and stupor, right hemiparesis, and aphasia; CT showed hemorrhages in the right caudate nucleus and left frontal lobe, laboratory tests including antibodies and acute phase reactants normal; pan-angiography showed: a pattern of vasculitis of trunk branches in cerebral arteries and occlusion of the inferior longitudinal sinus; with a diagnosis of possible PVCNS. Drainage of frontal hemorrhage and biopsy was performed, which confirmed the diagnosis; beginning treatment with methylprednisolone bolus and cyclophosphamide, obtaining clinical improvement. Conclusions: PVCNS presents heterogeneous clinical manifestations of acquired neurological deficits; it is a challenge. Its diagnosis implies the existence of the following: a) the acquired neurological deficit, unexplained by another cause, b) angiographic or histopathological evidence of PVCNS, c) absence of systemic vasculitis or other condition that explains it.

REFERENCES

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2. Hajj-Ali RA, Calabrese LH. Central nervous system vasculitis: advances in diagnosis. Curr Opin Rheumatol. 2020; 32 (1): 41-46. doi: 10.1097/BOR.0000000000000676.

3. Wang LJ, Kong DZ, Guo ZN, Zhang FL, Zhou HW, Yang Y. Study on the clinical, imaging, and pathological characteristics of 18 cases with primary central nervous system vasculitis. J Stroke Cerebrovasc Dis. 2019; 28 (4): 920-928.