medigraphic.com
ISSN 0326-3428 (Print)
Órgano de difusión científica de la Asociación Nefrológica de Buenos Aires

2023, Number 3

<< Back Next >>

Rev Nefrol Dial Traspl 2023; 43 (3)

Comparison of different kidney diseases in patients with COVID-19: Clinical and radiological CT scores assessment

Firat N, Dheir H, Tocoglu A, Yaylaci S, Karacan A, Demirci T, Seda CE, Koroglu M, Bilal GA, Pinar M, Karabay O, Sipahi S

Language: English
References: 21
Page: 148-155
PDF size: 459.71 Kb.


ABSTRACT

Background: We aimed to investigate the clinical course and radiological involvements in different kidney diseases during the COVID-19 infection. Materials and Methods: The present study was conducted on 107 patients with COVID-19 having different kidney disease courses. Thirty patients with chronic kidney disease (CKD), 38 patients with maintenance hemodialysis (MHD), and 39 patients with renal transplantation (RT) were compared. Data on demographic characteristics, blood markers, in-hospital mortality and morbidities, and thorax CT scores were obtained. Results: RT patients were younger than the CKD groups (47.0 ± 11.4 vs. 71.8 ± 11.5 years, respectively; ‹ 0.001) and MHD patients (67.7 ± 10.2 years, p ‹ 0.001). C-reactive protein, procalcitonin, D-dimer, and ferritin values were significantly lower in RT patients (p ‹ 0.05). The acute kidney injury rate was lower in RT patients than in CKD (p = 0.007), and the rate of sepsis development was low compared to MHD and CKD groups (p = 0.004). The requirement for mechanical ventilation (p = 0.013) and the mortality rate were significantly lower in RT patients than in MHD patients (p = 0.008). Concerning total thorax CT score, there was no difference in MHD patients compared to other groups, whereas it was found to be lower in RT patients than in CKD (p = 0.002). Conclusion: The prognosis of COVID-19 infection varies in different kidney diseases regarding morbidity, mortality, and radiologic involvement.


REFERENCES

  1. Portolés J, Marques M, López-Sánchez P, ValdenebroM, Muñez E, Serrano ML, et al. chronic kidney diseaseand acute kidney injury in the COVID-19 Spanishoutbreak. Nephrol Dial Transplant. 2020; 35:1353-61.

  2. Cravedi P, Mothi SS, Azzi Y, Haverly M, FaroukSS, Pérez‐Sáez MJ, et al. COVID-19 and kidneytransplantation: Results from the TANGOInternational Transplant Consortium. Am J Transplant.2020; 20:3140-8.

  3. Ozturk S, Turgutalp K, Arici M, Odabas AR,Altiparmak MR, Aydin Z, et al. Mortality analysisof COVID-19 infection in chronic kidney disease,haemodialysis and renal transplant patients comparedwith patients without kidney disease: a nationwideanalysis from Turkey. Nephrol Dial Transplant. 2020;35:2083-95.

  4. Izcovich A, Ragusa MA, Tortosa F, Lavena MarzioMA, Agnoletti C, Bengolea A, et al. Prognostic factorsfor severity and mortality in patients infected withCOVID-19: A systematic review. PloS One. 2020;15:e0241955.

  5. Viasus D, García-Vidal C, Cruzado JM, Adamuz J,Verdaguer R, Manresa F, et al. Epidemiology, clinicalfeatures and outcomes of pneumonia in patients withchronic kidney disease. Nephrol Dial Transplant. 2011;26:2899-906.

  6. Henry BM, Lippi G. Chronic kidney disease isassociated with severe coronavirus disease 2019(COVID-19) infection. Int Urol Nephrol. 2020;52:1193-4.

  7. Flythe JE, Assimon MM, Tugman MJ, Chang EH,Gupta S, Shah J. et al. Characteristics and Outcomesof Individuals with Pre-existing Kidney Disease andCOVID-19 Admitted to Intensive Care Units in theUnited States. Am J Kidney Dis. 2021; 77:190-203.

  8. Akalin E, Azzi Y, Bartash R, Seethamraju H,Parides M, Hemmige V, et al. Covid-19 and KidneyTransplantation. N Engl J Med. 2020; 382:2475-7.

  9. Li K, Wu J, Wu F, Guo D, Chen L, Fang Z, et al.The Clinical and Chest CT Features Associated withSevere and Critical COVID-19 Pneumonia. InvestRadiol. 2020; 55:327-31.

  10. Wu J, Li J, Zhu G, Zhang Y, Bi Z, Yu Y, et al.Clinical Features of Maintenance HemodialysisPatients with 2019 Novel Coronavirus-InfectedPneumonia in Wuhan, China. Clin J Am Soc Nephrol.2020; 15:1139-45.

  11. Chung M, Bernheim A, Mei X, Zhang N, HuangM, Zeng X, et al. CT Imaging Features of 2019Novel Coronavirus (2019-nCoV). Radiology. 2020;295:202-7.

  12. Chang YC, Yu CJ, Chang SC, Galvin JR, Liu HM,Hsiao CH, et al. Pulmonary sequelae in convalescentpatients after severe acute respiratory syndrome:evaluation with thin-section CT. Radiology. 2005;236:1067-75.

  13. Hilbrands LB, Duivenvoorden R, Vart P, Franssen CF,Hemmelder MH, Jager KJ, et al. COVID-19-relatedmortality in kidney transplant and dialysis patients:results of the ERACODA collaboration. Nephrol DialTransplant. 2020; 35:1973-83.

  14. Dheir H, Sipahi S, Yaylaci S, Çetİn ES, GenÇ AB,Firat N, et al. Clinical course of COVID-19 diseasein immunosuppressed renal transplant patients. Turk JMed Sci. 2020; 51:428-434.

  15. Jager KJ, Kramer A, Chesnaye NC, Couchoud C,Sánchez-Álvarez JE, Garneata L, et al. Results from theERA-EDTA Registry indicate a high mortality due toCOVID-19 in dialysis patients and kidney transplantrecipients across Europe. Kidney Int. 2020; 98:1540-8.

  16. Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. TimeCourse of Lung Changes at Chest CT during Recoveryfrom Coronavirus Disease 2019 (COVID-19).Radiology. 2020; 295:715-21.

  17. Lieveld AWE, Azijli K, Teunissen BP, van HaaftenRM, Kootte RS, van den Berk IA, et al. ChestCT in COVID-19 at the ED: Validation of theCOVID-19 Reporting and Data System (CO-RADS)and CT Severity Score: A Prospective, Multicenter,Observational Study. Chest. 2021; 159:1126-35.

  18. Cheng Y, Luo R, Wang K, Zhang M, Wang Z,Dong L, et al. Kidney impairment is associated within-hospital death of patients with COVID-19. KidneyInt. 2020; 97:829-38.

  19. Peng S, Wang HY, Sun X, Li P, Ye Z, Li Q, et al. Earlyversus late acute kidney injury among patients withCOVID-19-a multicenter study from Wuhan, China.Nephrol Dial Transplant. 2020; 35:2095-102.

  20. Adapa S, Chenna A, Balla M, Merugu GP, KoduriNM, Daggubati SR, et al. COVID-19 PandemicCausing Acute Kidney Injury and Impact onPatients with Chronic Kidney Disease and RenalTransplantation. J Clin Med Res. 2020; 12:352.

  21. Docherty AB, Harrison EM, Green CA, HardwickHE, Pius R, Norman L, et al. Features of 20 133 UKpatients in hospital with covid-19 using the ISARICWHO Clinical Characterisation Protocol: prospectiveobservational cohort study. BMJ. 2020;369:m1985.




2020     |     www.medigraphic.com