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Medicina & Laboratorio

2023, Number 4

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Medicina & Laboratorio 2023; 27 (4)

Correlation between imaging findings and histopathological results in gastric adenocarcinoma

Márquez-Villanueva AE, Osorio GJ, Vásquez-Montoya JD, Cardona-Palacio A

Language: Spanish
References: 25
Page: 333-343
PDF size: 201.08 Kb.


ABSTRACT

Introduction. Gastric cancer is one of the leading causes of mortality in the world. Currently, preoperative staging of gastric cancer in most centers is performed with computerized axial tomography (CT). However, despite the implementation of imaging techniques in preoperative staging, previous studies and meta-analyses have shown that the correlation between preoperative staging by CT and definitive staging by pathology (gold standard) is far from perfect. The objective of this study was to determine the correlation between the results of the preoperative tomographic staging and the final anatomopathological staging, in patients diagnosed with gastric adenocarcinoma treated in a high complexity hospital in the period between 2016 and 2021. Methodology. A descriptive, retrospective study was carried out. The study population included all the patients with gastric adenocarcinoma who underwent preoperative tomography, gastrectomy, and anatomopathological study, during the care process at the San Vicente Fundación University Hospital in Medellin, Colombia. A convenience sample made up of all patients who met the inclusion criteria during the study period was taken. Results. 100 patients were included in the study, with a mean age of 62.5 years, the most frequent histological subtype was intestinal-type gastric adenocarcinoma in 49%. The overall accuracy of multidetector CT compared with the histopathological result for size of the tumor was 68%, with a sensitivity of 75% and a specificity of 65.3%. Sensitivity for detecting nodal involvement by CT was 80% (95%CI 67.57-89.77), specificity 43.1% (95%CI 28.5-58.97) and accuracy 64% (95%CI 53.79-73.36). Conclusions. Gastric adenocarcinoma is diagnosed in advanced stages. The use of CT in pre-surgical staging showed a greater ability to detect gastric carcinoma in advanced stages T3 and T4 compared to definitive histopathological results.


REFERENCES

  1. Sung H, Ferlay J, Siegel RL, Laversanne M,Soerjomataram I, Jemal A, et al. Global cancerstatistics 2020: GLOBOCAN estimates of incidenceand mortality worldwide for 36 cancersin 185 countries. CA Cancer J Clin 2021;71:209-249. https://doi.org/10.3322/caac.21660.

  2. Smyth EC, Verheij M, Allum W, CunninghamD, Cervantes A, Arnold D. Gastric cancer:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up. Ann Oncol2016;27:v38-v49. https://doi.org/10.1093/annonc/mdw350.

  3. Globocan. Colombia, Globocan 2020. Factsheets.Lyon, France: International Agencyfor Research on Cancer (IARC). Acceso 15 defebrero de 2023. Disponible en https://gco.iarc.fr/today/data/factsheets/populations/170-colombia-fact-sheets.pdf.

  4. Brome-Bohórquez MR, Paniagua-SaldarriagaLA, García-Montoya W, Pedroza-RodríguezJF, Ramírez-Posada OA. Situación del cáncerdepartamento de Antioquia. Año 2017. Gerenciade Salud Pública. Antioquia, Colombia:International Association of Cancer Registries(IARC); 2019. Acceso 15 de febrero de 2023.Disponible en https://www.dssa.gov.co/images/estadisticas/cancer/Perfil_Epidemiologio_Cancer_Version28_Mayo2019_Definitivo.pdf.

  5. Thun MJ, DeLancey JO, Center MM, JemalA, Ward EM. The global burden of cancer:priorities for prevention. Carcinogenesis2010;31:100-110. https://doi.org/10.1093/carcin/bgp263.

  6. Espejo-Romero H, Navarrete-Siancas J. Clasificaciónde los adenocarcinomas de estómago.Rev Gastroenterol Perú 2003;23:199-212.

  7. Blanco-Fernández O, Cantillo-García A, Rivera-Pallares J. Current focus of gastric cancer.Medicas UIS 2013;26:59-70.

  8. Waldum HL, Fossmark R. Types of gastriccarcinomas. Int J Mol Sci 2018;19. https://doi.org/10.3390/ijms19124109.

  9. Lauren P. The two histological main types ofgastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histoclinicalclassification. Acta Pathol MicrobiolScand 1965;64:31-49. https://doi.org/10.1111/apm.1965.64.1.31.

  10. Bonequi P, Meneses-González F, Correa P,Rabkin CS, Camargo MC. Risk factors for gastriccancer in Latin America: a meta-analysis.Cancer Causes Control 2013;24:217-231.https://doi.org/10.1007/s10552-012-0110-z.

  11. Fukagawa T, Katai H, Mizusawa J, NakamuraK, Sano T, Terashima M, et al. A prospectivemulti-institutional validity study to evaluate theaccuracy of clinical diagnosis of pathologicalstage III gastric cancer (JCOG1302A). GastricCancer 2018;21:68-73. https://doi.org/10.1007/s10120-017-0701-1.

  12. Amin MB, Greene FL, Edge SB, Compton CC,Gershenwald JE, Brookland RK, et al. TheEighth Edition AJCC Cancer Staging Manual:Continuing to build a bridge from a populationbasedto a more "personalized" approach tocancer staging. CA Cancer J Clin 2017;67:93-99. https://doi.org/10.3322/caac.21388.

  13. Terashima M, Yoshikawa T, Boku N, Ito S,Tsuburaya A, Iwasaki Y, et al. Current statusof perioperative chemotherapy for locally advancedgastric cancer and JCOG perspectives.Jpn J Clin Oncol 2020;50:528-534. https://doi.org/10.1093/jjco/hyaa005.

  14. López-Ramírez MA, Lever-Rosas CD, Motta-Ramírez GA, Rebollo-Hurtado V, Guzmán-Bárcenas J, Fonseca-Morales JV, et al. Correlaciónentre la estadificación tomográficapreoperatoria con los resultados histopatológicosdefinitivos en cáncer gástrico en elHospital Central Militar. Rev Gastroenterol Mex2017;82:210-216. https://doi.org/https://doi.org/10.1016/j.rgmx.2016.10.007.

  15. Hoyos-Valdelamar JC, Hernández-ValdelamarJA, Santos-Arrieta M. Caracterización delcáncer gástrico abordado por laparoscopia enun centro del caribe colombiano. Rev ColombCir 2020;35:575-582.

  16. Adrada JC, Calambás FH, Díaz JE, DelgadoDO, Sierra CH. Características sociodemográficasy clínicas en una población con cáncergástrico en el Cauca, Colombia. Rev ColombGastroenterol 2008;23:309-314.

  17. Portillo-Miño JD, Araujo-Prado LM, Melo-Yepes JM, Carlosama-Rosero YH. Característicassociodemográficas e histopatológicasen pacientes con cáncer gástrico en una poblacióncon alto riesgo en Colombia. Rev ColombGastroenterol 2021;36:18-23. https://doi.org/10.22516/25007440.544.

  18. Jaime-Suárez BM, García-Ríos LE, Martínez-Sánchez YL, Sánchez-Luna C, Sotelo-MartínezL, Medrano-Guzmán R. Utilidad de latomografía computada multidetector en la estadificacióndel cáncer gástrico. An Radiol Méx2014;13:202-217.

  19. Barros RH, Penachim TJ, Martins DL, AndreolloNA, Caserta NM. Multidetector computedtomography in the preoperative stagingof gastric adenocarcinoma. Radiol Bras 2015;48:74-80. https://doi.org/10.1590/0100-3984.2014.0021.

  20. Makino T, Fujiwara Y, Takiguchi S, TsuboyamaT, Kim T, Nushijima Y, et al. PreoperativeT staging of gastric cancer by multidetectorrow computed tomography. Surgery2011;149:672-679. https://doi.org/10.1016/j.surg.2010.12.003.

  21. de Boer NL, Brandt-Kerkhof AR, MadsenEV, Diepeveen M, van Meerten E, van EerdenRA, et al. Concomitant intraperitonealand systemic chemotherapy for extensive peritonealmetastases of colorectal origin: protocolof the multicentre, open-label, phase I,dose-escalation INTERACT trial. BMJ Open2019;9:e034508. https://doi.org/10.1136/bmjopen-2019-034508.

  22. Callaway MP, Bailey D. Staging computedtomography in upper GI malignancy. A surveyof the 5 cancer networks covered by the SouthWest Cancer Intelligence Service. Clin Radiol2005;60:794-800. https://doi.org/https://doi.org/10.1016/j.crad.2005.02.004.

  23. Mocellin S, Pasquali S. Diagnostic accuracyof endoscopic ultrasonography (EUS)for the preoperative locoregional staging ofprimary gastric cancer. Cochrane DatabaseSyst Rev 2015;2015:Cd009944. https://doi.org/10.1002/14651858.CD009944.pub2.

  24. Röcken C, Behrens HM. Validating the prognosticand discriminating value of the TNMclassificationfor gastric cancer - a critical appraisal.Eur J Cancer 2015;51:577-586. https://doi.org/10.1016/j.ejca.2015.01.055.

  25. Raluca-Ioana D, Dan Nicolae P, Alexandra B,Daniel I, Octavian A. The role of PET-CT in gastriccancer-A narrative review. Sudan J Med Sci2020;15:332-344. https://doi.org/10.18502/sjms.v15i3.7749.




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