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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2023, Number 10

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Ginecol Obstet Mex 2023; 91 (10)

Essential thrombocytosis of pregnancy onset. Case report and literature review

Haro GLM, Pérez RFR
Full text How to cite this article

Language: Spanish
References: 11
Page: 788-797
PDF size: 228.45 Kb.


Key words:

Myeloproliferative neoplasms, Pregnancy, Leukocytes, Antiplatelet agent, Thrombotic, Cesarean section, Essential thrombocythemia.

ABSTRACT

Background: The coexistence of myeloproliferative neoplasms during pregnancy may lead to maternal and fetal complications, and early detection is essential.
Clinical case: A 30-year-old primigravida. Prenatal examination revealed a significant increase in platelets and leukocytes. After exclusion of an infectious process and consultation with the haematologist, she was prescribed an antiplatelet agent. The pregnancy proceeded without thrombotic or haemorrhagic complications and was terminated by caesarean section at 40 weeks, indicated for lack of progress in labour. Specific treatment of the disease and follow-up were then initiated.
Methodology: Articles published in the last 20 years were searched in PubMed and Clinical Key databases using MeSH "essential thrombocythemia AND pregnancy", "haematological neoplasms AND pregnancy".
Results: We obtained 14 articles, of which 3 were excluded because they did not include pregnant women. The final review consisted of 11 articles.
Conclusions: Correct follow-up of antenatal care can warn of medical complications independent of pregnancy. In this case, timely intervention and involvement of other specialists is possible to confirm the diagnosis and make the best joint decision for the benefit of the mother and her unborn child.


REFERENCES

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  2. Skeith L, Carrier M, Robinson SE, Alimam S, Rodger MA.Risk of venous thromboembolism in pregnant womenwith essential thrombocythemia: a systematic review andmeta-analysis. Blood 2017; 129 (8): 934-39. https://doi.org/10.1182/blood-2016-09-728006

  3. Gangat N, Tefferi A. Myeloproliferative neoplasms andpregnancy: Overview and practice recommendations. AmJ Hematol 2021; 96 (3): 354-66. https://pubmed.ncbi.nlm.nih.gov/33296529/

  4. Guglielmelli P, Vannucchi AM. Current managementstrategies for polycythemia vera and essential thrombocythemia.Blood Reviews 2020; 42: 100714. https://doi.org/10.1016/j.blre.2020.100714

  5. Puyade M, Cayssials E, Pierre F, Pourrat O. Pregnancy andmyeloproliferative neoplasms: A retrospective monocentriccohort. Obstet Med 2017; 10 (4): 165. https://doi.org/10.1177/1753495x17708896

  6. How J, Leiva O, Bogue T, Fell GG, Bustoros MW, ConnellNT, et al. Pregnancy outcomes, risk factors, and cellcount trends in pregnant women with essential thrombocythemia.Leuk Res 2020; 98: 106-459. https://doi.org/10.1016/j.leukres.2020.106459

  7. Burbury K, Panigrahi A. Esssential thrombocythaemia andpregnancy—A need for prospective study and a consensuson its management. Leuk Res 2021; 102: 1-3. https://doi.org/10.1016/j.leukres.2021.106500

  8. İskender D, Yılmaz-Ergani S, Aksoy M, Tokgoz B, IbanogluMC, Kızıl Çakar M, et al. High rate of obstetric complicationsin patients with essential thrombocythemia. Cureus 2021;13 (12): e20449. doi:10.7759/cureus.20

  9. Umazume T, Yamada T, Akaishi R, Araki N, Nishida R, MorikawaM, et al. Essential thrombocythemia as a risk factorfor stillbirth. Thromb Res 2014; 133 (2): 158-61. https://doi.org/10.1016/j.thromres.2013.11.004

  10. Belčič Mikič T, Vratanar B, Pajič T, Anžej Doma S, DebeljakN, Preložnik Zupan I, et al. Is it possible to predict clonalthrombocytosis in triple-negative patients with isolatedthrombocytosis based only on clinical or blood findings?J Clin Med 2021; 10 (24): 5803. https://doi.org/10.3390/jcm10245803

  11. Valera MC, Parant O, Vayssiere C, Arnal JF, Payrastre B.Essential thrombocythemia and pregnancy. European JObstet Gynecol Reprod Biol 2011; 158 (2): 141-7. https://doi.org/10.1016/j.ejogrb.2011.04.040




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Ginecol Obstet Mex. 2023;91