2023, Number S1
<< Back Next >>
Sal Jal 2023; 10 (S1)
Microcystic adnexal carcinoma a clinical-diagnostic challenge
Sánchez-Tadeo MT, Ferguson-Rodríguez CA, Fajardo-Barajas D, Munguía-Sánchez JA, Carrillo-Manguart V, Alcázar-García LB
Language: Spanish
References: 12
Page: s51-55
PDF size: 257.82 Kb.
ABSTRACT
Introduction: the microquistic anexial carcinoma is rare, asymptomatic and malignant cutaneous neoplasm, it can display both ductal and follicular differentiation because is developed from a pluripotent adnexal keratinocyte. In caucasic people the average age of incidence is between the 60 to 70 years old. Most frecuently manifest as a unique, red plaque or papule, in those areas of skin which are exposed to sunlight in head and neck. Its presentation most of the times benign, results as a missed diagnosis and missed treatment that increases the risk of local invasion. There are a few cases of this carcinomas reported in medical literature, we have to keep it in mind like a differential diagnosis of facial neoplasms.
Clinical case: we present a case of a patient without risk factors to develop it and not in the average of presentation.
Conclusion: microcystic adnexal carcinoma is a rare neoplasm, slow growing, invasive and locally destructive, very rarely produces metastases; it is important to make the differential diagnosis with the most confused neoplasm, which is basal cell carcinoma and make use of extra tools such as immunohistochemistry and if necessary make consensus among experts.
REFERENCES
Gerall CD, Sippel MR, Yracheta JL, Hogan FS. Microcystic adnexal carcinoma: a rare, commonly misdiagnosed malignancy. Mil Med [Internet]. 2019;184(11-12):948-950. Available in: https://academic.oup.com/milmed/article/184/11-12/948/5498203
Elder DE. Lever's histopathology of the skin. Pennsylvania: Wolters Kluwer; 2015. pp. 1663-1667.
Kim DW, Lee G, Lam MB, Harris EJ, Lam AC, Thomas T, et al. Microcystic adnexal carcinoma of the face treated with definitive chemoradiation: a case report and review of the literature. Adv Radiat Oncol [Internet]. 2020;5(2):301-310. Available in: https://linkinghub.elsevier.com/retrieve/pii/S2452109419301733
Martorell-Calatayud A, Requena-Caballero C, Botella-Estrada R, Almenar-Medina S, Sanmartín-Jiménez O, Llombart-Cussac B, et al. Microcystic adnexal carcinoma: Mohs micrographic surgery as the treatment of choice. Actas Dermosifiliogr [Internet]. 2009;100(8):693-699. Available in: https://linkinghub.elsevier.com/retrieve/pii/S1578219009701519
Gordon S, Fischer C, Martin A, Rosman IS, Council ML. Microcystic adnexal carcinoma: a review of the literature. Dermatologic Surg [Internet]. 2017;43(8):1012-1016. Available in: https://journals.lww.com/00042728-201708000-00002
Goldstein DJ, Barr RJ, Cruz DJS. Microcystic adnexal carcinoma: a distinct clinicopathologic entity. Cancer [Internet]. 1982;50(3):566-572. Available in: https://onlinelibrary.wiley.com/doi/10.1002/1097-0142(19820801)50:3%3C566::AID-CNCR2820500330%3E3.0.CO;2-Q
Palamaras I, McKenna JD, Robson A, Barlow RJ. Microcystic adnexal carcinoma. Dermatologic Surg [Internet]. 2010;36(4):446-452. Available in: https://journals.lww.com/00042728-201004000-00002
Tse JY, Nguyen AT, Le LP, Hoang MP. Microcystic adnexal carcinoma versus desmoplastic trichoepithelioma. Am J Dermatopathol [Internet]. 2013;35(1):50-55. Available in: https://journals.lww.com/00000372-201302000-00008
Chiller K, Passaro D, Scheuller M, Singer M, McCalmont T, Grekin RC. Microcystic adnexal carcinoma. forty-eight cases, their treatment, and their outcome. Arch Dermatol [Internet]. 2000;136(11):1355-1359. Available in: http://archderm.jamanetwork.com/article.aspx?doi=10.1001/archderm.136.11.1355
Pugh TJ, Lee NY, Pacheco T, Raben D. Microcystic adnexal carcinoma of the face treated with radiation therapy: A case report and review of the literature. Head Neck [Internet]. 2012 Jul;34(7):1045–50. Available from: https://onlinelibrary.wiley.com/doi/10.1002/hed.21690
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, et al. Demographics and outcomes of microcystic adnexal carcinoma. J Am Acad Dermatol [Internet]. 2018;79(4):756-758. Available in: https://linkinghub.elsevier.com/retrieve/pii/S0190962218304602
Chaudhari SP, Mortazie MB, Blattner CM, Garelik J, Wolff M, Daulat J, et al. Treatments for microcystic adnexal carcinoma – A review. J Dermatolog Treat [Internet]. 2016;27(3):278-284. Available in: https://www.tandfonline.com/doi/full/10.3109/09546634.2015.1089351