Mercado U

Language: Spanish
References: 6
Page: 53-58
PDF size: 260.51 Kb.

ABSTRACT

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in treating pain, fever, and inflammation by inhibiting prostaglandin synthesis. However, these agents have a substantial burden of side effects. As a result of the search for a better aspirin, cyclooxygenase-2 (COX-2) was discovered and specific COX-2 antagonists or coxibs were synthesized. Anti-inflammatory benefits were maintained, gastric ulcers occurred, and decreased vascular prostacyclin production (antithrombotic) without a change in thromboxane levels (prothrombotic) caused hypertension and thrombosis and withdrawal of some coxibs.

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