Reyes JB, Torres GS, González GM, Ramírez RA

Language: Spanish
References: 13
Page: 35-38
PDF size: 192.73 Kb.

ABSTRACT

Cutaneous Rosai-Dorfman disease is limited to the skin without lymphadenopathy or other extracutaneous involvement. The etiology is still unclear, the theories suggest that it is a reactive process rather than a neoplastic disorder. The lesions are heterogenous and not very specific, the most common site of lesions is the face and the most common morphology is the nodule. The histologic hallmark is emperipolesis and positive s-100 protein in immunohistochemistry. After the diagnosis it is important to rule out extracutaneous involvement. The clinical course is usually benign and self-limited. We report a 75-year-old female with a presence of skin lesions in arms, forearms, tights, and lumbar, characterized by asymptomatic confluent red nodules of four months’ history. The histopathology showed clusters of pleomorphic, large, foamy histiocytes with polymorphonuclears, plasma cells and lymphocytes in their cytoplasm. We ruled out an extracutaneous involvement and confirmed cutaneous Rosai-Dorfman disease.

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