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ISSN 2007-3178 (Print)
Asociación Mexicana de Cirugía Bucal y Maxilofacial, Colegio Mexicano de Cirugía Bucal y Maxilofacial, A.C.

2024, Number 3

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Rev Mex Cir Bucal Maxilofac 2024; 20 (3)

Identification of HPV subtypes 16 and 18 in squamous cell carcinoma of the Oral Cavity at the Maxillofacial Surgery Department of Roosevelt Hospital

García VÁM, Hurtado CI, Matta RJ

Language: Spanish
References: 26
Page: 97-104
PDF size: 421.25 Kb.


ABSTRACT

Introduction: studies have shown that certain types of Human Papillomavirus (HPV) can influence the development of squamous cell carcinoma of the oral cavity, primarily the high-risk viruses, HPV 16 and HPV 18. Objective: to determine the presence of HPV subtypes 16 and 18 in patients diagnosed with squamous cell carcinoma of the oral cavity. Material and methods: a descriptive cross-sectional study was conducted. A non-probabilistic sample of 20 consecutive cases of squamous cell carcinoma in the oral cavity, aged over 18 years, of both sexes, was included. IHC HVP16 E6 and IHC HVP18 E6 immunohistochemical stains were performed. The results were analyzed using descriptive statistics in Excel tables. Results: male patients accounted for 11 cases (61.1%), with an average age ranging between 51-60 years (50%), and the majority of patients were from Guatemala city (44.4%). The anatomical site of preference was the lateral borders of the tongue (44.4%). Two patients reported alcohol consumption. HPV was detected in 18 patient samples (90%). HPV 16 was present in isolation in 13 cases (65%) and accompanied by HPV 18 in 5 more cases (25%). HPV 18 was not found in isolation. Conclusion: high-risk human papillomavirus subtypes 16 and 18 are present in 90% of patients with squamous cell carcinoma of the oral cavity treated at the Stomatology Department of Roosevelt Hospital.


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