medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2025, Number 6

<< Back Next >>

Ginecol Obstet Mex 2025; 93 (6)

Systemic lupus erythematosus: a comprehensive approach to obstetric syndromes. A literature review

Molina GS, Rodríguez ZT, Cháves GBD, Romero MNE, Ramírez RMC, Chica WD, Arreaza GM

Language: Spanish
References: 24
Page: 210-220
PDF size: 231.39 Kb.


ABSTRACT

Objective: To provide an updated overview of systemic lupus erythematosus with a focus on obstetric syndromes associated with the disease.
Methodology: A search was conducted in Scopus, PubMed, and Web of Science databases using the following terms: systemic lupus erythematosus, pregnancy, obstetric syndromes, pregnancy complications, pregnancy management in patients with lupus, maternal and fetal outcomes. Original articles, systematic reviews, and meta-analyses published in English or Spanish within the last 10 years were included.
Results: : Twenty-four articles met the inclusion criteria. Two independent reviewers selected articles that met the inclusion and exclusion criteria. In the event of disagreement, a third reviewer discussed the results to reach a consensus. The following data were extracted from the selected articles: title and authors, year of publication, type of study, population studied, and main results, for information synthesis and writing.
Conclusions: The close relationship between Systemic lupus erythematosus and obstetric syndromes is highlighted, as well as its general context mediated by inflammation.


REFERENCES

  1. Zucchi D, Fischer-Betz R, Tani C. Pregnancy in systemiclupus erythematosus. Best Pract Res Clin Rheumatol 2023 Dec;37(4):101860. https://doi.org/10.1016/j.berh.2023.101860

  2. Cajamarca-Baron J, Sanmiguel-Reyes C, Bedoya-Loaiza JE,Castañeda-Gonzalez JP, et al. Maternal and fetal outcomesin Latin American SLE pregnancies: A systematic reviewand meta-analysis. Autoimmun Rev 2025; 24 (4). https://pubmed.ncbi.nlm.nih.gov/39809408/

  3. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The “greatObstetrical Syndromes” are associated with disorders ofdeep placentation. Am J Obstet Gynecol 2011; 204 (3):193-201. https://pubmed.ncbi.nlm.nih.gov/21094932/

  4. Kiriakidou M, Ching CL. In the clinic® systemic lupus erythematosus.Ann Intern Med 2020; 172 (11): ITC82-96. https://pubmed.ncbi.nlm.nih.gov/32479157/

  5. Zamora-Medina M del C, Orozco-Guillén OA, Domínguez-Quintana M, Romero-Diaz J. Systemic lupus erythematosusand pregnancy: Strategies before, during and after pregnancyto improve outcomes. Rev Colomb Reumatol 2021; 28 (Suppl1): 53-65. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232021000500053&lng=en

  6. Wallace DJ, Hahn BH. Dubois’ lupus erythematosus. 9thed. Philadelphia: Elsevier. 2018. https://books.google.cl/books?hl=es&lr=&id=tj9JR3IITy8C&oi=fnd&pg=PP1493&dq=Wallace+DJ,+Hahn+BH.+Dubois%E2%80%99+Lupus+Erythematosus+and+Related+Syndromes.+9th+ed.+Philadelphia:+Elsevier%3B+2018.+&ots=npe8LVCdjP&sig=2kMWn3VOHohyvfc9LfMRE9ITSiw

  7. Tsokos GC. Systemic lupus erythematosus. N Engl J Med2011; 365 (22): 2110-21. https://pubmed.ncbi.nlm.nih.gov/22129255/

  8. D’Cruz DP, Khamashta MA, Hughes GR. Systemic lupuserythematosus. Lancet 2007; 369 (9561): 587-96. https://pubmed.ncbi.nlm.nih.gov/17307106/

  9. Doria A, Laccarino L, Sarzi-Puttini P, Ghirardello A, et al.Estrogens in pregnancy and systemic lupus erythematosus.Ann NY Acad Sci 2006; 1069: 247-56. https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1196/annals.1351.022

  10. Rahman A, Isenberg DA. Systemic lupus erythematosus.N Engl J Med 2008; 358 (9): 929-39. https://pubmed.ncbi.nlm.nih.gov/18305268/

  11. Buyon JP, Clancy RM. Maternal autoantibodies and congenitalheart block: Mediators, markers, and therapeutic approach.Semin Arthritis Rheum 2003; 33 (3): 140-54. https://www.wellesu.com/10.1016/j.semarthrit.2003.09.002

  12. Redman CWG, Sargent IL. Placental stress and pre-eclampsia:A revised view. Placenta.2009; 30 (Suppl): 38-42.https://pubmed.ncbi.nlm.nih.gov/19138798/

  13. Revaux A, Mekinian A, Nicaise P, Bucourt M, et al. Antiphospholipidsyndrome and other autoimmune diseases associatedwith chronic intervillositis. J Reprod Immunol.2015;291 (6): 1229-36. https://sci-hub.se/https://link.springer.com/article/10.1007/s00404-014-3536-6

  14. Sammaritano LR. Management of systemic lupus erythematosusduring pregnancy. Annu Rev Med 2017; 68: 271-85. https://pubmed.ncbi.nlm.nih.gov/27686021/

  15. Østensen M, Förger F. Management of RA medications inpregnant patients. Nat Rev Rheumatol 2009; 5 (7): 382-90.https://pubmed.ncbi.nlm.nih.gov/19506586/

  16. Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, et al.EULAR recommendations for women’s health and themanagement of family planning, assisted reproduction,pregnancy and menopause in patients with systemic lupuserythematosus and/or antiphospholipid syndrome. AnnRheum Dis 2017; 76 (3): 476-85. https://pubmed.ncbi.nlm.nih.gov/27457513/

  17. Urowitz MB, Gladman DD. Evolving spectrum of mortalityand morbidity in SLE. Lupus 1999; 8 (4): 253-5. https://pubmed.ncbi.nlm.nih.gov/10413200/

  18. Hoffman MK. The great obstetrical syndromes and theplacenta. BJOG 2023; 130 (S3): 8-5. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.17613

  19. Li HH, Sai LT, Tian S, Liu Y, et al. Sexual dimorphisms ofprotein-coding gene profiles in placentas from womenwith systemic lupus erythematosus. Front Med (Lausanne)

  20. 2022; 9. https://pubmed.ncbi.nlm.nih.gov/35372436/20. Torres-Torres J, Espino-y-Sosa S, Martinez-Portilla R,Borboa-Olivares H, et al. A narrative review on the pathophysiologyof preeclampsia. Int J Mol Sci 2024; 25 (14).https://pubmed.ncbi.nlm.nih.gov/39062815/

  21. Castro-Gutierrez A, Young K, Bermas BL. Pregnancy andmanagement in women with rheumatoid arthritis, systemiclupus erythematosus, and obstetric antiphospholipidsyndrome. Rheum Dis Clin North Am 2022; 48 (2): 341-53.https://doi.org/10.1016/j.rdc.2022.02.009

  22. Hu Z, Gao R, Huang W, Wang H, Qin L. Effect of hydroxychloroquineon lupus activity, preeclampsia and intrauterinegrowth restriction in pregnant women with systemic lupuserythematosus and/or antiphospholipid syndrome: A systematicreview and meta-analysis. J Clin Med 2023; 12 (2).https://pubmed.ncbi.nlm.nih.gov/36675415/

  23. Silver R, Craigo S, Porter F, Osmundson SS, et al. Societyfor maternal-fetal medicine consult series #64: Systemiclupus erythematosus in pregnancy. Am J Obstet Gynecol2023; 228 (3): B41-60. https://pubmed.ncbi.nlm.nih.gov/36084704/

  24. Parikh SV, Almaani S, Brodsky S, Rovin BH. Update onlupus nephritis: Core curriculum 2020. Am J Kidney Dis2020; 76 (2): 265-81. https://pubmed.ncbi.nlm.nih.gov/32220510/




2020     |     www.medigraphic.com