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2025, Number 4

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Rev ADM 2025; 82 (4)

Survival in human papillomavirus-related carcinoma of the tongue: a systematic review.

Benítez-Moreno LF, Tovío-Martínez E, Morales-Gutiérrez MA

Language: Spanish
References: 44
Page: 213-225
PDF size: 412.44 Kb.


ABSTRACT

Introduction: oropharyngeal squamous cell carcinoma, which includes base of the tongue cancer, has variable survival rates depending on the location and metastatic status, with human papilloma virus (HPV) present in 80% of cases and serotypes 16, 18, 31, and 45 as risk factors. Objectives: to evaluate the relationship between oral HPV infection and survival in patients with squamous cell carcinoma of the tongue, considering the methodological quality and risk of bias in the available studies. Material and methods: a systematic review of studies published in databases such as PubMed and SciELO was carried out until December 2021, selecting those that analyzed patients with tongue cancer and HPV detection, excluding studies without anatomical differentiation or comparability. Results: twelve studies with a total of 77,649 patients were included, of which 10 showed a possible improvement in survival in HPV-positive patients, although methodological limitations and risk of bias were identified. Conclusions: these findings could influence the treatment of squamous cell carcinoma of the tongue, but further studies are needed to assess the impact of vaccination status and other prognostic factors.


REFERENCES

  1. Bommakanti KK, Abiri A, Han AY, Goshtasbi K, Kuan EC, St John MA. Stage-specific survival in young patients with oral tongue squamous cell carcinoma. Otolaryngol Head Neck Surg. 2023; 168 (3): 398-406. doi: 10.1177/01945998221101191.

  2. Arredondo Montero J, Bronte Anaut M, López-Andrés N, Martín-Calvo N, Bardají Pascual C. A Tumor at the Base of the Tongue. J Pediatr. 2022; 242: 256-257. doi: 10.1016/j.jpeds.2021.11.005.

  3. You EL, Henry M, Zeitouni AG. Human papillomavirus-associated oropharyngeal cancer: review of current evidence and management. Curr Oncol. 2019; 26 (2): 119-123. doi: 10.3747/co.26.4819.

  4. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68 (6): 394-424. doi: 10.3322/caac.21492.

  5. Vivero Mendoza WA, Mendoza Robles JL. Virus del Papiloma Humano y su relación con el Cáncer Orofaríngeo. Rev San Gregorio. 2021; 1 (48): 123-148. doi:10.36097/rsan.v0i48.1771.

  6. Ferreira AK, Carvalho SH, Granville-Garcia AF, Sarmento DJ, Agripino GG, Abreu MH et al. Survival and prognostic factors in patients with oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2021; 26 (3): e387-e392. doi: 10.4317/medoral.24242.

  7. Massa ST, Osazuwa-Peters N, Adjei-Boakye E, Walker RJ, Ward GM. Comparison of the financial burden of survivors of head and neck cancer with other cancer survivors. JAMA Otolaryngol Head Neck Surg. 2019; 145 (3): 239-249. doi: 10.1001/jamaoto.2018.3982.

  8. Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017; 67 (1): 51-64. doi: 10.3322/caac.21384.

  9. Ryu HJ, Kim EK, Cho BC, Yoon SO. Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity. Head Neck. 2019; 41 (1): 198-207. doi: 10.1002/hed.25507.

  10. Syrjanen K, Syrjanen S, Lamberg M, Pyrhonen S, Nuutinen J. Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. Int J Oral Surg. 1983; 12 (6): 418-424. doi: 10.1016/s0300-9785(83)80033-7.

  11. Contreras W, Venegas B. Virus Papiloma Humano en cáncer oral y orofaríngeo: revisión de la literatura. Int J Odontostomat. 2015; 9 (3): 427-435. doi: 10.4067/S0718-381X2015000300012.

  12. Rebolledo Cobos M, Arango-Fernández H, Rebolledo-Cobos R, Alonso-Brujes I. Rol del virus del papiloma humano en el desarrollo de carcinoma oral: una revisión. Av Odontoestomatol. 2016; 32 (3): 135-144.

  13. Urbano-del Valle S, Tovío-Martínez E, Contreras-García N. Cáncer de cabeza y cuello asociado al virus del papiloma humano. Presentación de caso. Rev Habanera Cienc Méd. 2019; 18 (3): 450-460.

  14. Gallegos HJF, Minauro MG, Apresa T, Arias CH, Hernández SM, Flores DR et al. Cáncer de lengua y virus del papiloma humano (VPH). Acta Med GA. 2023; 21 (s1): s36-s40. doi: 10.35366/109560.

  15. Ernster JA, Sciotto CG, O'Brien MM, Finch JL, Robinson LJ, Willson T et al. Rising incidence of oropharyngeal cancer and the role of oncogenic human papilloma virus. Laryngoscope. 2007; 117 (12): 2115-2128. doi: 10.1097/MLG.0b013e31813e5fbb.

  16. Gal TJ, O'Brien KJ, Chen Q, Huang B. Clinical vs microscopic extranodal extension and survival in oropharyngeal carcinoma in the Human Papillomavirus era. Otolaryngol Head Neck Surg. 2020; 162 (5): 693-701. doi: 10.1177/0194599820910431.

  17. Garnaes E, Frederiksen K, Kiss K, Andersen L, Therkildsen MH, Franzmann MB et al. Double positivity for HPV DNA/p16 in tonsillar and base of tongue cancer improves prognostication: Insights from a large population-based study. Int J Cancer. 2016; 139 (11): 2598-2605. doi: 10.1002/ijc.30389.

  18. Goel AN, Frangos M, Raghavan G, Sangar S, Lazaro S, Wang MB et al. Survival impact of treatment delays in surgically managed oropharyngeal cancer and the role of human papillomavirus status. Head Neck. 2019; 41 (6): 1756-1769. doi: 10.1002/hed.25643.

  19. Hall SF, Liu FF, O'Sullivan B, Shi W, Rohland S, Griffiths R et al. Did the addition of concurrent chemotherapy to conventional radiotherapy improve survival for patients with HPV+ve and HPV-ve Oropharynx cancer? A population-based study. Br J Cancer. 2017; 117 (8): 1105-1112. doi: 10.1038/bjc.2017.275.

  20. Hobbs AJ, Brockton NT, Matthews TW, Chandarana SP, Bose P, Guggisberg K et al. Primary treatment for oropharyngeal squamous cell carcinoma in Alberta, Canada: a population-based study. Head Neck. 2017; 39 (11): 2187-2199. doi: 10.1002/hed.24889.

  21. Iyer NG, Dogan S, Palmer F, Rahmati R, Nixon IJ, Lee N et al. Detailed analysis of clinicopathologic factors demonstrate distinct difference in outcome and prognostic factors between surgically treated hpv-positive and negative oropharyngeal cancer. Ann Surg Oncol. 2015; 22 (13): 4411-4421. doi: 10.1245/s10434-015-4525-0.

  22. Kurokawa T, Nakagawa T, Matsusaka K, Fukuyo M, Mima M, Misawa K et al. Establishment of epigenetic markers to predict irradiation efficacy against oropharyngeal cancer. Cancer Sci. 2020; 111 (4): 1407-1416. doi: 10.1111/cas.14338.

  23. Lu DJ, Luu M, Mita A, Scher K, Shiao SL, Yoshida EP et al. Human papillomavirus-associated oropharyngeal cancer among patients aged 70 and older: Dramatically increased prevalence and clinical implications. Eur J Cancer. 2018; 103: 195-204. doi: 10.1016/j.ejca.2018.08.015.

  24. Lu DJ, Luu M, Nguyen AT, Scher KS, Clair JM, Mita A et al. Survival outcomes with concomitant chemoradiotherapy in older adults with oropharyngeal carcinoma in an era of increasing human papillomavirus (HPV) prevalence. Oral Oncol. 2019; 99: 104472. doi: 10.1016/j.oraloncology.2019.104472.

  25. Melchers LJ, Mastik MF, Samaniego-Cameron B, van Dijk BA, de Bock GH, van der Laan BF et al. Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: more than meets the eye. Br J Cancer. 2015; 112 (8): 1349-1357. doi: 10.1038/bjc.2015.99.

  26. Ren J, Xu W, Su J, Ren X, Cheng D, Chen Z et al. Multiple imputation and clinico-serological models to predict human papillomavirus status in oropharyngeal carcinoma: an alternative when tissue is unavailable. Int J Cancer. 2020; 146 (8): 2166-2174. doi: 10.1002/ijc.32548.

  27. de Morais EF, Mafra RP, Gonzaga AKG, de Souza DLB, Pinto LP, da Silveira ÉJD. Prognostic factors of oral squamous cell carcinoma in young patients: a systematic review. J Oral Maxillofac Surg. 2017; 75 (7): 1555-1566. doi: 10.1016/j.joms.2016.12.017.

  28. Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP et al. Human papillomavirus infection and oral squamous cell carcinoma - a systematic review. Braz J Otorhinolaryngol. 2021; 87 (3): 346-352. doi: 10.1016/j.bjorl.2020.10.017.

  29. AAOM Clinical Practice Statement: Subject: Oral cancer examination and screening. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122 (2): 174-175. doi: 10.1016/j.oooo.2016.04.009.

  30. Mitchell DA, Kanatas A, Murphy C, Chengot P, Smith AB, Ong TK. Margins and survival in oral cancer. Br J Oral Maxillofac Surg. 2018; 56 (9): 820-829. doi: 10.1016/j.bjoms.2018.06.021.

  31. Deneuve S, Guerlain J, Dupret-Bories A, Majoufre C, Philouze P, Ceruse P et al. Oral tongue squamous cell carcinomas in young patients according to their smoking status: a GETTEC study. Eur Arch Otorhinolaryngol. 2022; 279 (1): 415-424. doi: 10.1007/s00405-021-06793-7.

  32. Hsiao JR, Chang CC, Lee WT, Huang CC, Ou CY, Tsai ST et al. The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinoma. Carcinogenesis. 2018; 39 (6): 778-787. doi: 10.1093/carcin/bgy053.

  33. Sundermann BV, Uhlmann L, Hoffmann J, Freier K, Thiele OC. The localization and risk factors of squamous cell carcinoma in the oral cavity: a retrospective study of 1501 cases. J Craniomaxillofac Surg. 2018; 46 (2): 177-182. doi: 10.1016/j.jcms.2017.10.019.

  34. Patel P, Singhal PM, Lakhera KK, Chatterjee A, Babu A, Singh S et al. Predicting recurrence in oral cavity cancers: a review of 116 patients with buccal mucosa carcinoma in northwestern India. Arch Craniofac Surg. 2023; 24 (5): 211-217. doi: 10.7181/acfs.2023.00311.

  35. Piemonte ED, Lazos JP, Gilligan GM, Panico RL, Werner LC, Yang YH et al. Chronic mechanical irritation enhances the effect of tobacco and alcohol on the risk of oral squamous cell carcinoma: a case-control study in Argentina. Clin Oral Investig. 2022; 26 (10): 6317-6326. doi: 10.1007/s00784-022-04584-w.

  36. Gharat SA, Momin M, Bhavsar C. Oral squamous cell carcinoma: current treatment strategies and nanotechnology-based approaches for prevention and therapy. Crit Rev Ther Drug Carrier Syst. 2016; 33 (4): 363-400. doi: 10.1615/CritRevTherDrugCarrierSyst.2016016272.

  37. Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S et al. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023; 15 (1): 44. doi: 10.1038/s41368-023-00249-w.

  38. Ettinger KS, Ganry L, Fernandes RP. Oral cavity cancer. Oral Maxillofac Surg Clin North Am. 2019; 31 (1): 13-29. doi: 10.1016/j.coms.2018.08.002.

  39. Wang MB, Liu IY, Gornbein JA, Nguyen CT. HPV-Positive oropharyngeal carcinoma: a systematic review of treatment and prognosis. Otolaryngol Head Neck Surg. 2015; 153 (5): 758-769. doi: 10.1177/0194599815592157.

  40. Sedghizadeh PP, Billington WD, Paxton D, Ebeed R, Mahabady S, Clark GT et al. Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis. Oral Oncol. 2016; 54: 15-27. doi: 10.1016/j.oraloncology.2016.01.002.

  41. Ahmadi N, Chan M, Huo YR, Sritharan N, Chin RY. Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): a systematic review and meta-analysis. Surgeon. 2019; 17 (1): 6-14. doi: 10.1016/j.surge.2018.04.009.

  42. Zupancic M, Kostopoulou ON, Holzhauser S, Lukoseviciute M, Jylha C, Marklund L et al. Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival. Oral Oncol. 2024; 151: 106749. doi: 10.1016/j.oraloncology.2024.106749.

  43. Kim SI, Lee JW, Eun YG, Lee YC. A SEER-based analysis of trends in HPV-associated oropharyngeal squamous cell carcinoma. Infect Agent Cancer. 2024; 19 (1): 29. doi: 10.1186/s13027-024-00592-5.

  44. Wu B, Zhang T, Dai N, Luo D, Wang X, Qiao C et al. Global research trends in tongue cancer from 2000 to 2022: bibliometric and visualized analysis. Clin Oral Investig. 2024; 28 (2): 130. doi: 10.1007/s00784-024-05516-6.




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