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2025, Number 4

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Rev ADM 2025; 82 (4)

Use of chlorhexidine to reduce alveolitis as a postoperative complication of third molar surgery: meta-analysis.

Rivera CJ, Mendoza SJI

Language: Spanish
References: 22
Page: 226-231
PDF size: 339.34 Kb.


ABSTRACT

Third molar surgery is the most common surgery performed by the oral and maxillofacial surgeon, nevertheless postoperative complications can be present in many ways after surgery, the dry socket is the most common postoperative complication with a prevalence of 1-4% after surgery. Dry socket is characterized by intense pain and delayed cicatrization. The objective of this study is to demonstrate the effectiveness of chlorhexidine to decrease dry socket after third molar surgery through a metaanalisis. The results of this study were 1,142 patients that use chlorhexidine, from this number only 8.74% developed dry socket versus patients that didn't use it had a high prevalence of 27.5% with a large range of difference. The results of this investigation demonstrated that the use of chlorhexidine reduces the incidence of dry socket reducing bacteria and maintaining a clean surgical area, as well as helping to fix and secure the clot, allowing proper healing.


REFERENCES

  1. Rodríguez-Sánchez F, Rodríguez-Andrés C, Arteagoitia-Calvo I. Does chlorhexidine prevent alveolar osteitis after third molar extractions? Systematic review and meta-analysis. J Oral Maxillofac Surg. 2017; 75 (5): 901-914. doi: 10.1016/j.joms.2017.01.002

  2. Cardoso CL, Rodrigues MTV, Ferreira Júnior O, Garlet GP, de Carvalho PSP. Clinical concepts of dry socket. J Oral Maxillofac Surg. 2010; 68 (8): 1922-1932. doi: 10.1016/j.joms.2009.09.085

  3. Mamoun J. Dry socket etiology, diagnosis, and clinical treatment techniques. J Korean Assoc Oral Maxillofac Surg. 2018; 44 (2): 52. doi: 10.5125/jkaoms.2018.44.2.52

  4. Bonanthaya K, Panneerselvam E, Manuel S, Kumar VV, Rai A. Cirugía oral y maxilofacial para el clínico. Singapur, Singapur: Springer; 2022.

  5. Hupp JR, Ellis III E, Tucker MR. Cirugía oral y maxilofacial contemporánea. Ciencias de la Salud de Elsevier; 2014. p. 174-187.

  6. Katzung B. Farmacología básica y clínica. Manual Moderno; 2005.

  7. Poppolo Deus F, Ouanounou A. Clorhexidina en odontología: farmacología, usos y efectos adversos. Int Dent J. 2022; 72 (3): 269-277. doi: 10.1016/j.identj.2022.01.005

  8. Haraji A, Rakhshan V. Single-dose intra-alveolar chlorhexidine gel application, easier surgeries, and younger ages are associated with reduced dry socket risk. J Oral Maxillofac Surg. 2014; 72 (2): 259-265. doi: 10.1016/j.joms.2013.09.023

  9. Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA. Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2006; 11 (2): E179-E184.

  10. Sridhar V, Wali GG, Shyla HN. Evaluation of the perioperative use of 0.2% chlorhexidine gluconate for the prevention of alveolar osteitis after the extraction of impacted mandibular third molars: a clinical study. J Maxillofac Oral Surg. 2011; 10 (2): 101-111. doi: 10.1007/s12663-011-0206-0

  11. Haraji A, Rakhshan V. Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomized clinical trial. J Oral Rehabil. 2015; 42 (3): 209-219. doi: 10.1111/joor.12230

  12. Requena-Calla S, Funes-Rumiche I. Effectiveness of intra-alveolar chlorhexidine gel in reducing dry socket following surgical extraction of lower third molars. A pilot study. J Clin Exp Dent. 2016; 8 (2): e160-e163. doi: 10.4317/jced.52444

  13. Haraji A, Rakhshan V, Khamverdi N, Alishahi HK. Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. J Orofac Pain. 2013; 27 (3): 256-262. doi: 10.11607/jop.1142

  14. Inamdar, Goswami, Khadri. Prevention of dry socket using chlorhexidine gel and ornidazole gel in impacted mandibular third molar: A comparative randomized prospective study on 30 patients. J Int Oral Health. 2015; 7 (11): 41-46. Disponible en: https://www.proquest.com/docview/1750715666?sourcetype=Scholarly%20Journals

  15. Hamid S, Memon M, Ali R, Shams S. Use of chlorhexidine 0.2% gel to prevent alveolar osteitis in mandibular third molar surgical extraction. Prof Med J. 2020; 27 (08): 1606-1611. doi: 10.29309/tpmj/2020.27.08.4264

  16. Khan A, Sharjeel B, Farhan R, Fahad U, Syed M, Tuba H. Clinical efficacy of single dose chlorhexidine gel application in molars extractions - A randomized clinical. 2016. Available from: (2016). https://www.semanticscholar.org/paper/Clinical-Efficacy-of-Single-Dose-Chlorhexidine-Gel-Khan-Bashir/9053fb941babea050930712a3dab42dfd2e40a9b

  17. Ahmedi J, Ahmedi E, Agani Z, Hamiti V, Recica B, Tmava-Dragusha A. The efficacy of 1% chlorhexidine gel on the reduction of dry socket occurrence following surgical third molar extraction— pilot study. Open J Stomatol. 2014; 04 (03): 152-160. doi: 10.4236/ojst.2014.43023

  18. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 2008; 66 (3): 441-445. doi: 10.1016/j.joms.2007.06.641

  19. Torres-Lagares D, Gutierrez-Perez JL, Infante-Cossio P, Garcia-Calderon M, Romero-Ruiz MM, Serrera-Figallo MA. Randomized, double-blind study on effectiveness of intra-alveolar chlorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. Int J Oral Maxillofac Surg. 2006; 35 (4): 348-351. doi: 10.1016/j.ijom.2005.08.002

  20. Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, Magallanes-Abad N, Flores-Ruiz R, Basallote-Garcia M et al. Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. J Oral Maxillofac Surg. 2010; 68 (6): 1322-1326. doi: 10.1016/j.joms.2009.08.022

  21. Freudenthal N, Sternudd M, Jansson L, Wannfors K. A double-blind randomized study evaluating the effect of intra-alveolar chlorhexidine gel on alveolar osteitis after removal of mandibular third molars. J Oral Maxillofac Surg. 2015; 73 (4): 600-605. doi: 10.1016/j.joms.2014.08.035

  22. Rubio-Palau J, Garcia-Linares J, Hueto-Madrid JA, González-Lagunas J, Raspall-Martin G, Mareque-Bueno J. Effect of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on the incidence of alveolar osteitis following the extraction of mandibular third molars. A double-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2015; 20 (1): e117-e122. doi: 10.4317/medoral.20009




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