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2025, Number 1

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Med Crit 2025; 39 (1)

Tracheal gas insufflation due to refractory hypoxemia under protective mechanical ventilation in a patient with pulmonary embolism secondary to protein S deficiency

Giraldo SJM
Full text How to cite this article 10.35366/121125

DOI

DOI: 10.35366/121125
URL: https://dx.doi.org/10.35366/121125

Language: Spanish
References: 26
Page: 80-84
PDF size: 249.29 Kb.


Key words:

refractory hypoxemia, mechanical ventilation, protein S deficiency, pulmonary embolism, tracheal gas insufflation.

ABSTRACT

Thromboembolic pulmonary disease manifests itself in various ways during its clinical presentation, resulting in serious physiological implications that severely alter the shunt, ratio ventilation/perfusion, and subsequently mechanical pulmonary properties dynamic and static. However, the severity of its clinical course is directly related to the cause of thrombosis whose determine endothelial dysfunction and inflammation with which it is accompanied. Endogenous glycoprotein deficiencies are always accompanied by serious alveolar capillary disturbances that generate severe lung injury, which requires rescue strategies to rapidly normalize gas exchange in order to avoid lung damage related to ventilator use. We present the clinical case of a young adult who developed refractory hypoxemia requiring tracheal gas insufflation.


REFERENCES

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Med Crit. 2025;39