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2025, Number 3

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Rev Mex Pediatr 2025; 92 (3)

Multiorgan procurement in a pediatric patient with a pineal gland tumor

García-Jiménez M, Villasís-Keever MÁ, Hernández-Neria MD, Montiel-Luna EM, Morales-Rivera E, Siordia-Reyes AG

Language: Spanish
References: 12
Page: 115-119
PDF size: 1200.88 Kb.


ABSTRACT

Introduction: transplantation is the treatment that can be definitive for many serious diseases. In general, adults are the main organ donors, even for pediatric patients. The indications for donation have been established for several decades. In some guidelines, cancer is considered a contraindication; however, there are studies where successful cases of donation have been documented, especially from patients with central nervous system (CNS) tumours. Clinical case: we present an adolescent diagnosed with germ cell tumor of the pineal gland, who began with clinical signs of severe cranial hypertension. After diagnosis, surgery was performed to remove the tumor, but in the postoperative period there were complications leading to brain death. The parents authorized multi-organ donation after a conversation with a multidisciplinary team. The heart, liver, kidneys and corneas were obtained. Conclusion: given the low frequency of donation from pediatric patients, it seems necessary to have an in-depth understanding of the donation criteria, including pathologies such as cancer, to increase transplant opportunities.


REFERENCES

  1. Organización Mundial de la Salud (OMS). Trasplante de órganos y tejidos humanos. Informe del Director General [Internet]. Ginebra: OMS; 2022. Disponible en: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://apps.who.int/gb/ebwha/pdf_files/WHA75/A75_41-sp.pdf

  2. Hsu B, Bondoc A, Cuenca AG, Hittle Gigli K, Laventhal N, Nakagawa T. Pediatric organ donation and transplantation: Across the care continuum. Pediatrics. 2023; 152(2): e2023062923. doi: 10.1542/peds.2023-062923.

  3. Monge-Zamorano M, Luis-Yanes MI, Gil-Villena M, Hernández-González MJ, García-Nieto VM. Trasplante de órganos sólidos y donación. Conceptos generales para la consulta del pediatra. Canarias Pediátrica. 2024; 47: 299-311.

  4. Nakagawa TA, Shemie SD, Dryden-Palmer K, Parshuram CS, Brierley J. Organ donation following neurologic and circulatory determination of death. Pediatr Crit Care Med. 2018; 19(8S suppl. 2): S26-S32. doi: 10.1097/PCC.0000000000001518.

  5. Centro Nacional de Trasplantes. Guía del Coordinador Hospitalario de Donación de Órganos y Tejidos con Fines de Trasplante en México [Internet]. México: Centro Nacional de Trasplantes; 2019. Disponible en: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://cenatra.salud.gob.mx/transparencia/Guxa_del_Coordinador_H.pdf

  6. Kauffman HM, Cherikh WS, McBride MA, Cheng Y, Hanto DW. Deceased donors with a past history of malignancy: an organ procurement and transplantation network/united network for organ sharing update. Transplantation. 2007; 84(2): 272-274. doi: 10.1097/01.tp.0000267919.93425.fb.

  7. Hynes CF, Ramakrishnan K, Alfares FA, Endicott KM, Hammond-Jack K, Zurakowski D et al. Risk of tumor transmission after thoracic allograft transplantation from adult donors with central nervous system neoplasm-A UNOS database study. Clin Transplant. 2017; 31(4). doi: 10.1111/ctr.12919.

  8. Lee LA, Okpere A, Martin DA, Mahoney M, James L, Avitzur Y et al. Variability in pediatric and neonatal organ offering, acceptance and utilization: a survey of Canadian pediatric transplant programs and organ donation organizations. Front Transplant. 2024; 3: 1458563. doi: 10.3389/frtra.2024.1458563.

  9. Greenhall GHB, Rous BA, Robb ML, Brown C, Hardman G, Hilton RM et al. Organ transplants from deceased donors with primary brain tumors and risk of cancer transmission. JAMA Surg. 2023; 158(5): 504-513. doi: 10.1001/jamasurg.2022.8419.

  10. Kauffman HM, McBride MA, Delmonico FL. First report of the United Network for Organ Sharing Transplant Tumor Registry: donors with a history of cancer. Transplantation. 2000; 70(12): 1747-1751. doi: 10.1097/00007890-200012270-00014.

  11. Ince V, Ersan V, Ozdemir F, Barut B, Koc C, Isik B et al. Deceased donor liver transplantation from donors with central nervous system malignancy: Experience of the Inonu University. North Clin Istanb. 2017; 4(3): 213-217. doi: 10.14744/nci.2017.74436.

  12. Cavaliere R, Schiff D. Donor transmission of primary brain tumors: a neurooncologic perspective. Transplant Rev. 2004; 18(4): 204-213. doi: /10.1016/j.trre.2004.09.003.




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