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Revista de Nefrología, Diálisis y Trasplante

ISSN 0326-3428 (Print)
Órgano de difusión científica de la Asociación Nefrológica de Buenos Aires
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2025, Number 3

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Rev Nefrol Dial Traspl 2025; 45 (3)

Farabursen: Potential new treatment for polycystic kidney disease by inhibiting the microRNA miR-17

Negri AL
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Language: Spanish
References: 19
Page: 127-129
PDF size: 137.76 Kb.


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REFERENCES

  1. Igarashi P, Somlo S. Genetics and pathogenesis ofpolycystic kidney disease. J Am Soc Nephrol. 2002;13(9):2384-2398.

  2. Harris PC, Torres VE. Polycystic kidney disease.Annu Rev Med. 2009;60:321-337.

  3. Patel V, Chowdhury R, Igarashi P. Advances in thepathogenesis and treatment of polycystic kidneydisease. Curr Opin Nephrol Hypertens.2009;18(2):99-106.

  4. Lin F, et al. Kidney-specific inactivation of theKIF3A subunit of kinesin-II inhibits renalciliogenesis and produces polycystic kidney disease.Proc Natl Acad Sci USA. 2003;100(9):5286-5291.

  5. Patel V, et al. Acute kidney injury and aberrantplanar cell polarity induce cyst formation in micelacking renal cilia. Hum Mol Genet.2008;17(11):1578-1590.

  6. Firth MC, Pheasant M, Mattick JS. The amazingcomplexity of the human transcriptome. Eur J HumGenet 2005;13(8):894-897.

  7. Hombach S, Kretz M. Non-coding RNAs:Classification, biology and functioning. Adv ExpMed Biol 2016;937:3-17.

  8. Kim VN, Han J, Siomi MC. Biogenesis of smallRNAs in animals. Nat Rev Mol Cell Biol2009;10(2):126-139.

  9. Bartel DP. MicroRNAs: Target recognition andregulatory functions. Cell. 2009;136(2):215-233.

  10. Mendell JT, Olson EN. MicroRNAs in stresssignaling and human disease. Cell. 2012;148(6): 1172-1187.

  11. Small EM, Olson EN. Pervasive roles of microRNAsin cardiovascular biology. Nature. 2011;469(7330):336-342.

  12. van Rooij E, Marshall WS, Olson EN. TowardmicroRNA-based therapeutics for heart disease: Thesense in antisense. Circ Res. 2008;103(9):919-928.

  13. Patel V, et al. MicroRNAs regulate renal tubulematuration through modulation of Pkd1. J Am SocNephrol. 2012;23(12):1941-1948.

  14. Patel V, Noureddine L. MicroRNAs and fibrosis.Curr Opin Nephrol Hypertens. 2012;21(4):410-416.

  15. Pandey P, Qin S, Ho J, Zhou J, Kreidberg JA.Systems biology approach to identify transcriptomereprogramming and candidate microRNA targetsduring the progression of polycystic kidney disease.BMC Syst Biol. 2011;5:56.

  16. Pandey P, et al. Microarray-based approach identifiesmicroRNAs and their target functional patterns inpolycystic kidney disease. BMC Genomics. 2008;9:624.

  17. Patel V, Williams D. miR-17∼92 miRNA clusterpromotes Kidney Cyst growth in polycystic kidneydisease. PNAS 2013;10(26):10765-17070.

  18. Ramalingam H, Yheskel M ,Patel V. Modulation ofPolycystic Kidney disease by non-coding RNAs.Cell Signal 2020 Jul: 71:109548. doi: 10.1016/j.cellsig.2020.109548.Epub 2020 Jan 23.

  19. Edmund C Lee, et al. Discovery and preclinicalevaluation of anti-miR-17 oligonucleotide RGLS4326for the treatment of polycystickidney disease. NatCommun. 2019;10(1):4148




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Rev Nefrol Dial Traspl. 2025;45