2026, Number 2
<< Back Next >>
Acta Med 2026; 24 (2)
Index of renal resistance in patients with shock septic and its variability dependent on vasopressor dose admitted to the intensive therapy unit
Meyer TM, Morales AJA, Esponda PJG
Language: Spanish
References: 14
Page: 87-92
PDF size: 484.10 Kb.
ABSTRACT
Introduction: hemodynamic management in critically ill patients focuses on maintaining optimal cardiac output and blood pressure. In the context of septic shock, vasopressors are used to achieve this. Renal perfusion is evaluated as a success parameter through diuresis and creatinine clearance, as variations in blood pressure directly impact perfusion once the autoregulation threshold is reached. The VeXus protocol uses Doppler ultrasound to classify venous congestion and predict acute kidney injury.
Objective: to compare the baseline renal resistance index measured by ultrasonography upon admission to the intensive care unit (ICU) in patients diagnosed with sepsis and to assess changes in this index with the use of Norepinephrine.
Material and methods: descriptive, longitudinal, prospective, single-center study evaluating variations in the renal resistance index using Norepinephrine.
Results: in a sample of 42 patients, no significant changes were observed in the index of the dose of norepinephrine, with a correlation of 0.2369033.
Conclusions: no changes were observed in the renal resistance index in patients requiring Norepinephrine during their ICU stay.
REFERENCES
Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet. 2005; 365 (9457): 417-430
Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med. 2004; 351 (2): 159-169.
Beaubien-Souligny W, Rola P, Haycock K, Bouchard J, Lamarche Y, Spiegel R et al. Quantifying systemic congestion with point-of-care ultrasound: development of the venous excess ultrasound grading system. Ultrasound J. 2020; 12: (1): 16.
Deruddre S, Cheisson G, Mazoit JX, Vicaut E, Benhamou D, Duranteau J. Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography. Intensive Care Med. 2007; 33 (9): 1557-1562.
Correa TD, Vuda M, Takala J, Djafarzadeh S, Silva E, Jakob SM. Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Crit Care. 2013; 17 (1): R21.
Dubin A, Pozo MO, Casabella CA, Pálizas F, Murias G, Moseinco MC, et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care. 2009; 13 (3): R92.
Darmon M, Schortgen F, Vargas F, Liazydi A, Schlemmer B, Brun-Buisson C et al. Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med. 2011; 37 (1): 68-76.
Lerolle N, Guérot E, Faisy C, Bornstain C, Diehl JL, Fagon JY. Renal failure in septic shock: predictive value of Doppler-based renal arterial resistive index. Intensive Care Med. 2006; 32 (10): 1553-1559.
Anile A, Ferrario S, Campanello L, Orban MA, Castiglione G. Renal resistive index: a new reversible tool for the early diagnosis and evaluation of organ perfusion in critically ill patients: a case report. Ultrasound J. 2019; 11 (1): 23.
Rozemeijer S, Haitsma Mulier JLG, Rottgering JG, Elbers PWG, Spoelstra-de Man AME, Tuinman PR et al. Renal resistive index: response to shock and its determinants in critically ill patients. Shock. 2019; 52 (1): 43-51.
Di Nicolò P, Granata A. Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions. J Nephrol. 2019; 32 (4): 527-538.
Koratala A, Reisinger N. Venous excess Doppler ultrasound for the nephrologist: pearls and pitfalls. Kidney Med. 2022; 4 (7): 100482.
Ninet S, Schnell D, Dewitte A, Zeni F, Meziani F, Darmon M. Doppler-based renal resistive index for prediction of renal dysfunction reversibility: a systematic review and meta-analysis. J Crit Care. 2015; 30 (3): 629-635.
Dewitte A, Coquin J, Meyssignac B, Joannès-Boyau O, Fleureau C, Roze H et al. Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury. Crit Care. 2012; 16 (5): R165.