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2024, Number 2-3

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Rev Neurol Neurocir Psiquiat 2024; 52 (2-3)

Forced normalization after right temporal lobe epilepsy surgery: a case report

San-Juan D, Wong-Valenzuela EI
Full text How to cite this article 10.35366/122637

DOI

DOI: 10.35366/122637
URL: https://dx.doi.org/10.35366/122637

Language: Spanish
References: 6
Page: 74-77
PDF size: 397.92 Kb.


Key words:

epilepsy, psychosis, epilepsy surgery, forced normalization, surgical treatment.

ABSTRACT

Introduction: comorbidity between psychosis and epilepsy can occur in different ways. The phenomenon of forced normalization (NF) is characterized by the disappearance of epileptiform activity on the electroencephalogram or seizure freedom after treatment in patients with epilepsy accompanied by the appearance of psychotic symptoms. Case presentation: we present a 44-year-old woman with temporal lobe epilepsy, in whom right temporal lobectomy was effective in controlling her seizures, but who developed NF. Conclusion: the incidence of NF is more frequent in temporal lobe epilepsy. Psychotic flares due to NF are mainly managed by modifying the antiseizure treatment that originated it, however, in patients that underwent epilepsy surgery this is not always possible.


REFERENCES

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  2. Calle-López Y, Ladino LD, Benjumea-Cuartas V, Castrillón-Velilla DM, Téllez-Zenteno JF, Wolf P. Forced normalization: a systematic review. Epilepsia. 2019; 60 (8): 1610-1618. doi: 10.1111/epi.16276.

  3. Krishnamoorthy ES, Trimble MR, Sander JW, Kanner AM. Forced normalization at the interface between epilepsy and psychiatry. Epilepsy Behav. 2002; 3 (4): 303-308. doi: 10.1016/s1525-5050(02)00052-5.

  4. Krishnamoorthy ES, Trimble MR. Forced normalization: clinical and therapeutic relevance. Epilepsia. 1999; 40 Suppl 10: S57-S64. doi: 10.1111/j.1528-1157.1999.tb00886.x.

  5. Zhang S, Xu M, Liu ZJ, Feng J, Ma Y. Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications. World J Psychiatry. 2020; 10 (6): 125-138. doi: 10.5498/wjp.v10.i6.125.

  6. Thom M, Kensche M, Maynard J, Liu J, Reeves C, Goc J et al. Interictal psychosis following temporal lobe surgery: dentate gyrus pathology. Psychol Med. 2014; 44 (14): 3037-3049. doi: 10.1017/S0033291714000452.




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Rev Neurol Neurocir Psiquiat. 2024;52