Fajardo GDS, Reynoso CAM, Rosa VN, González CV, Granados GM, Palacios SDA

Language: Spanish
References: 12
Page: 174-177
PDF size: 1196.33 Kb.

ABSTRACT

Osteoradionecrosis (ORN) is a serious complication that can occur after radiation therapy to the head and neck region. It is characterized by loss of vitality, exposure, and lack of healing of the maxillary and mandibular bones. This condition can cause pain, infections, fractures, and a significant decline in the patient's quality of life. Treatment options go from conservative approaches like antibiotics, hyperbaric oxygen therapy, pentoxifylline, and tocopherol, to surgical procedures. A comprehensive approach is essential to control the disease and preserve patient´s function and well-being.

REFERENCES

1. Fan H, Kim SM, Cho YJ, Eo MY, Lee SK, Woo KM. New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol. Biomater Res. 2014; 18: 13.

2. Márquez STG, Minerva DAC, Echeverría y Pérez E, Malpica SEB. Osteorradionecrosis: experiencia en el hospital General de México. Gac Mex Oncol. 2011; 10 (5): 269-277.

3. Gallegos-Hernández JF, Reyes-Vivanco A, Arias-Ceballos H, Minauro-Muñoz GG, Ortiz-Maldonado AL, García-Ruíz D, et al. Osteroradionecrosis (ONR) mandibular como efecto colateral del tratamiento del cáncer de cabeza y cuello: factores que la inducen. Gac Med Mex. 2016; 152: 730-733.

4. Deshpande SS, Thakur MH, Dholam K, Mahajan A, Arya S, Juvekar S. Osteoradionecrosis of the mandible: through a radiologist's eyes. Clin Radiol. 2015; 70 (2): 197-205.

5. Singh A, Huryn JM, Kronstadt KL, Yom SK, Randazzo JR, Estilo CL. Osteoradionecrosis of the jaw: a mini review. Front Oral Health. 2022; 3: 980786.

6. Tartaroti NC, Marques MM, Naclério-Homem MDG, Migliorati CA, Zindel DMC. Antimicrobial photodynamic and photobiomodulation adjuvant therapies for prevention and treatment of medication-related osteonecrosis of the jaws: Case series and long-term follow-up. Photodiagnosis Photodyn Ther. 2020; 29: 101651.

7. Jacobson AS, Buchbinder D, Hu K, Urken ML. Paradigm shifts in the management of osteoradionecrosis of the mandible. Oral Oncol. 2010; 46 (11): 795-801.

8. Delanian S, Lefaix JL. The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 2004; 73 (2): 119-131.

9. Somay E, Yilmaz B, Kucuk A, Topkan E. Quality of life changes in patients with osteoradionecrosis and their measurement. Journal of Advances in Medicine and Medical Research. 2022; 34 (21): 48-61.

10. Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983; 41 (5): 283-288.

11. Márquez STG, Minerva DAC, Echevarría y Pérez E, Malpica SEB. Osteorradionecrosis: experiencia en el Hospital General de México. Gac Mex Oncol. 2011; 10 (5): 269-277.

12. Lee IJ, Koom WS, Lee CG, Kim YB, Yoo SW, Keum KC, et al. Risk factors and dose-effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients. Int J Radiat Oncol Biol Phys. 2009; 75 (4): 1084-1091.