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Organo Oficial de la Sociedad Mexicana de Urología
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2025, Number 5

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Rev Mex Urol 2025; 85 (5)

Bilateral testicular non-seminomatous germ cell tumor: case report

Beltrán-Suárez E, Luna-Palencia RL, Soria-Cespedes D, Becerril-Cholula L, Martínez-Zarraluqui A
Full text How to cite this article

Language: Spanish
References: 10
Page: 1-8
PDF size: 225.10 Kb.


Key words:

Orchiectomy, Chemotherapy, Nonseminomatous germ cell tumor.

ABSTRACT

Clinical case description: a 32-year-old man with an increase in the volume of the left testicle and a decrease in the size of the right testicle, in addition to the presence of pain. A testicular ultrasound reported probable bilateral testicular neoplasia, while the contrast-enhanced tomography indicated a left testicular lesion suggestive of embryonal cell carcinoma. We performed a bilateral radical orchiectomy, and pathology reported a mixed germ cell tumor in both testicles. It was determined to be a non-seminomatous germ cell tumor stage IIIC, so the patient received chemotherapy, responding satisfactorily.
Clinical implications: the development of testicular germ cell tumors (TGCT) is generally associated with risk factors such as cryptorchidism and hypospadias. However, although our patient is in the age range related to the development of TGCT, he did not present these factors but did have an advanced clinical stage whose survival is lower in relation to earlier stages.
Relevance: the timely diagnosis and appropriate treatment of a non-seminomatous germ cell tumor stage IIIC enabled our patient to respond. Currently, he is monitoring.
Conclusions: survival in advanced clinical stage TGCT requires timely diagnosis and treatment, as well as follow-up, given the different complications that may arise.


REFERENCES

  1. Sung H, Ferlay J, Siegel RL, LaversanneM, Soerjomataram I, Jemal A, et al. GlobalCancer Statistics 2020: GLOBOCAN Estimatesof Incidence and Mortality Worldwide for 36Cancers in 185 Countries. CA: a cancer journalfor clinicians. 2021;71(3): 209–249. https://doi.org/10.3322/caac.21660.

  2. Siegel RL, Miller KD, Jemal A. Cancer statistics,2018. CA: a cancer journal for clinicians.2018;68(1): 7–30. https://doi.org/10.3322/caac.21442.

  3. Oldenburg J, Berney DM, Bokemeyer C,Climent MA, Daugaard G, Gietema JA, etal. Testicular seminoma and non-seminoma:ESMO-EURACAN Clinical Practice Guidelinefor diagnosis, treatment and follow-up. Annals ofOncology: Official Journal of the European Societyfor Medical Oncology. 2022;33(4): 362–375.https://doi.org/10.1016/j.annonc.2022.01.002.

  4. Patrikidou A, Cazzaniga W, Berney D,Boormans J, de Angst I, Di Nardo D, et al.European Association of Urology Guidelineson Testicular Cancer: 2023 Update. EuropeanUrology. 2023;84(3): 289–301. https://doi.org/10.1016/j.eururo.2023.04.010.

  5. Arranz Arija JA, Del Muro XG, Caro RL,Méndez-Vidal MJ, Pérez-Valderrama B,Aparicio J, et al. SEOM-GG clinical guidelinesfor the management of germ-cell testicularcancer (2023). Clinical & Translational Oncology:Official Publication of the Federation of SpanishOncology Societies and of the National CancerInstitute of Mexico. 2024;26(11): 2783–2799.https://doi.org/10.1007/s12094-024-03532-2.

  6. Gillessen S, Sauvé N, Collette L, Daugaard G,de Wit R, Albany C, et al. Predicting Outcomesin Men With Metastatic NonseminomatousGerm Cell Tumors (NSGCT): Results From theIGCCCG Update Consortium. Journal of ClinicalOncology: Official Journal of the American Societyof Clinical Oncology. 2021;39(14): 1563–1574.https://doi.org/10.1200/JCO.20.03296.

  7. Tanuma K, Kawai K, Nitta S, Shiga M,Kawahara T, Negoro H, et al. Improved survivalof poor-risk non-seminomatous germ cell tumorpatients: real-world data from a single institutein Japan. Japanese Journal of Clinical Oncology.2023;53(1): 74–79. https://doi.org/10.1093/jjco/hyac151.

  8. Kirby M. Testicular cancer: low testosteroneand the metabolic syndrome. Trends in Urology& Men’s Health. 2020;11(1): 12–17. https://doi.org/10.1002/tre.728.

  9. Mulhall JP, Trost LW, Brannigan RE, KurtzEG, Redmon JB, Chiles KA, et al. Evaluationand Management of Testosterone Deficiency:AUA Guideline. The Journal of Urology.2018;200(2): 423–432. https://doi.org/10.1016/j.juro.2018.03.115.

  10. Nicu AT, Medar C, Chifiriuc MC, GradisteanuPircalabioru G, Burlibasa L. Epigenetics andTesticular Cancer: Bridging the Gap BetweenFundamental Biology and Patient Care.Frontiers in Cell and Developmental Biology.2022;10: 861995. https://doi.org/10.3389/fcell.2022.861995.




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Rev Mex Urol. 2025;85