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2025, Number 3

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Investigación en Discapacidad 2025; 11 (3)

Effects of aging on skeletal muscle and the impact of exercise on muscle health in older adults

Cabrera-del Sol H, Coral-Vázquez RM, Cano-Martínez LJ

Language: Spanish
References: 74
Page: 114-121
PDF size: 910.82 Kb.


ABSTRACT

One of the most common phenomena during aging is sarcopenia, characterized by the loss of skeletal muscle mass, strength, and function. This work reviews the main molecular and cellular mechanisms involved in the progressive deterioration of aging muscle, such as the shift from type II to type I muscle fibers, infiltration of fibroadipose tissue, fibrosis, mitochondrial metabolic dysfunction, and satellite cell senescence. Additionally, the beneficial effects of physical exercise will be addressed, including its role in promoting mitochondrial biogenesis, myokine expression, muscle tissue vascularization, and various epigenetic regulations that support the improvement of muscle function.


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