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Órgano oficial de la Asociación Mexicana de Medicina Transfusional A.C.

2026, Number 1

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Rev Mex Med Transfus 2026; 18 (1)

Anti-D or Anti-G? A diagnostic challenge: a clinical case report

Pereira I, Rodriguez A, Rivas G, Pereyra S, Rodriguez I

Language: Spanish
References: 13
Page: 28-32
PDF size: 246.83 Kb.


ABSTRACT

We report the case of a 46-year-old Caucasian female, blood group A RhD-negative, with a history of five pregnancies and three previous transfusions with A RhD-negative blood. The patient presented to the emergency department with acute, poorly tolerated anemia, requiring a blood transfusion. Routine immunohematological studies (ABO typing and irregular antibody screening) identified anti-D and anti-C antibodies. Suspecting the presence of an anti-G antibody, advanced immunohematological studies were ordered to characterize the alloimmunization profile. The diagnostic steps necessary to differentiate between the simultaneous presence of anti-D and anti-C antibodies versus an anti-G antibody are detailed, a distinction of particular importance for preventing anti-D alloimmunization, especially in women of childbearing age. The studies confirmed the presence of anti-G and anti-C antibodies, a finding of significant relevance for both transfusion management and obstetric follow-up.


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