2026, Number 1
DRESS syndrome in a pediatric patient: an infrequent diagnosis with high morbidity and mortality
Morales PEJ, Mejía LA, Jiménez PEN, Muñoz PLE, Sandoval SF
Full text
10.35366/123527
Language: Spanish
References: 7
Page: 11-15
PDF size: 1946.91 Kb.
ABSTRACT
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, uncommon, and potentially life-threatening delayed hypersensitivity reaction associated with exposure to various medications. It is characterized by extensive cutaneous rash, fever, hematologic abnormalities, and possible systemic involvement, which makes early recognition challenging, particularly in the pediatric population. We report the case of a 16-year-old male patient with a history of chronic kidney disease who developed rapidly progressive cutaneous erythema, mucocutaneous involvement, and fever following the recent initiation of allopurinol. Laboratory studies revealed eosinophilia and leukopenia. The diagnosis was established based on clinical and laboratory findings using the RegiSCAR criteria, classifying the case as possible DRESS syndrome, with histopathological confirmation obtained through skin biopsy. The suspected drug was discontinued, and treatment with systemic corticosteroids and intravenous immunoglobulin was initiated, resulting in favorable clinical evolution without evidence of systemic organ involvement. This case highlights the importance of early recognition and multidisciplinary management to improve patient outcomes.REFERENCES