medigraphic.com

2026, Number 2

<< Back Next >>

Enf Infec Microbiol 2026; 46 (2)

Unusual case of longitudinally extensive transverse myelitis secondary to Mycobacterium bovis

Callejas-Arroyo BE, Domínguez-Garcidueñas B, Soriano-Navarro E, Ramos Sánchez R, García-Minamy JI, Vega-Rivera C, Ramírez-González LE

Language: Spanish
References: 17
Page: 91-96
PDF size: 528.90 Kb.


ABSTRACT

Longitudinally extensive transverse myelitis (letm) is a myelopathy of inflammatory (infectious or autoimmune) and non-inflammatory (neoplastic and traumatic) etiology. Mycobacterium bovis, a species common in Mexico but rare in other parts of the world, was identified as the causative agent in the following case report from a 35-year-old male recently diagnosed with tuberculous meningoencephalitis, who, while being treated, his clinical condition worsened due to vasculopathy and letm. After receiving steroids, only the sensitive radicular component improved. Excluding other causes, we started second-line treatment for tuberculosis and reevaluated the patient after six months with the modified Rankin scale (mrs) without finding improvement or progression. tb myelitis is a devastating condition that should be considered as a cause of letm in endemic regions.


REFERENCES

  1. Salari, M., Zaker Harofte, B. y Etemadifar, M., “Longitudinalextensive transverse myelitis due to tuberculosis:a case report”, Neuroradiology J, 2023, 36 (2): 224-228.

  2. Trebst, C., Raab, P., Voss, E.V., Rommer, P., Abu-Mugheisib,M., Zettl, UK. et al., “Longitudinal extensive transversemyelitis— it’s not all neuromyelitis optic”, Nat RevNeurol, 2011, 7 (12): 688-698.

  3. Khan, M.I., Ravindra, Garg, K., Rizvi, I., Malhotra, H.S.et al., “Tuberculous myelitis: a prospective follow-upstudy”, Neurological Sciences, 2022, 1: 5615-5624.

  4. Fang, L., Gong, Y., Han, K., Lv ,Y., Li, M. y Wang, J.,“Longitudinally extensive transverse myelitis with mycobacteriumtuberculosis infection”, Acta Neurol Belg,2023, 123 (1): 243-246.

  5. Noh, M.S.F.M., Bahari, N. y Rashid, A.M.A., “Tuberculousmyelopathy associated with longitudinally extensive lesion:a clinicoradiological review of reported cases”, JClin Neurol, 2020, 16 (3): 369-375.

  6. Jiang, Y., Xu, X., Guo, Z., Liu, Y., Lin, J., Suo, L. et al.,“Myelitis: a common complication of tuberculous meningitispredicting poor outcome”, Front Neurol, 2022,13: 830029.

  7. Kumar Abhishek, A., Kalyan Kumar, B., Sarkar, A., Ghosh,R., Mandal, A., Swaika, B. et al., “Tubercular longitudinallyextensive transverse myelitis (letm)”, J Family MedPrim Care, 2021, 10 (2): 1057-1060.

  8. Wasay, M., Arif, H., Khealani, B. y Ahsan, H., “Neuroimagingof tuberculous myelitis: analysis of ten cases and reviewof literature”, J Neuroimaging, 2006, 16 (3): 197-205.

  9. Coclitu, C., Mergeani, A., Parvu, T., Rusu, O., Ciobotaru,A., Bajenaru, O. et al., “An uncommon cause oflongitudinally extensive transverse myelitis”, Maedica(Bucarest), 2016, 11 (3): 245.

  10. Bello-López, J.M., León-García, G., Rojas-Bernabé, A.,Fernández-Sánchez, V., García-Hernández, O., MancillaRámirez, J. et al., “Morbidity trends and risk of tuberculosis:Mexico 2007-2017”, Can Respir J, 2019.

  11. Katrak, S.M., “Central nervous system tuberculosis”, JNeurol Sci, 2021, 421: 117278.

  12. Thwaites, G., Fisher, M., Hemingway, C., Scott, G., Solomon,T. e Innes, J., “British Infection Society guidelinesfor the diagnosis and treatment of tuberculosis of thecentral nervous system in adults and children”, J Infect,2009; 59 (3): 167-187.

  13. Treatment for tb disease | treatment | tb | cdc. Disponibleen: https://www.cdc.gov/tb/esp/topic/treatment/tbdisease.htm.

  14. “Manual operativo de la oms sobre la tuberculosis.Módulo 4: Tratamiento. Tratamiento de la tuberculosisfarmacosensible”. Disponible en: https://www.who.int/es/publications/i/item/9789240050761.

  15. Geiseler, P.J., Manis, R.D. y Maddux, M.S., “Dosage ofantituberculous drugs in obese patients”, Am Rev RespirDis, 1985, 131 (6): 944-946.

  16. Esteban, J. y Muñoz-Egea, M.C., “Mycobacterium bovisand other uncommon members of the Mycobacteriumtuberculosis complex”, Microbiol Spectr, 2016, 4 (6).

  17. Milián-Suazo, F., Pérez-Guerrero, L., Arriaga-Díaz, C. yEscartín-Chávez, M., “Molecular epidemiology of humancases of tuberculosis by Mycobacterium bovis inMexico”, Prev Vet Med, 2010, 97 (1): 37-44.




2020     |     www.medigraphic.com