2026, Number 1
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Arch Med Urg Mex 2026; 18 (1)
Pathophysiology of septic shock. Part one
Mendez de Jesus IA, Guerrero-Navarrete L, González-Ramírez B, García-Pantoja MC, Domínguez-Briones RA, Urbina-García DP
Language: Spanish
References: 20
Page: 48-55
PDF size: 630.99 Kb.
ABSTRACT
Sepsis remains a challenge in critically ill patients; although understanding
of its pathophysiology and treatment guidelines have
evolved, outcomes remain discouraging, with high morbidity and
mortality rates. This has resulted in a massive consumption of material
and human resources and has placed healthcare services worldwide
under severe strain, creating a need for extraordinary control
measures—such as expert meetings to approve guidelines and directives
for its identification and management.
REFERENCES
Koyama K, Katayama S, Muronoi T, Tonai K, Goto Y, Koinuma T,et al. Time course of immature platelet count and its relation tothrombocytopenia and mortality in patients with sepsis. PLoS One[Internet]. 2018 [citado 2025 jun 29];13(1):e0192064. Disponiblehttp://dx.doi.org/10.1371/journal.pone.0192064.
Kempker JA, Rudd KE, Wang HE, Martin GS. Epidemiology ofsepsis from the International Classification of Diseases, Ninth Revisionto the Tenth Revision: a direct application of the Institute forHealth Metrics and Evaluation case definition to hospital dischargedata. Crit Care Med. 2020 Dec;48(12):1881–1884. doi:10.1097/CCM.0000000000004577. PMID: 33009097.
Perdomo Quintero D, Zambrano Torres OE. Choque séptico: Pasosclaves en el servicio de urgencias. RFS [Internet]. 2023 dic 2[citado 2025 mar 27];15(2):117–35. Disponible https://journalusco.edu.co/index.php/rfs/article/view/3906
Mendez de Jesus IA. Código sepsis en urgencias. Arch Med UrgMéx [Internet]. 2024;16(1):8–11. Disponible en: https://www.medigraphic.com/pdfs/urgencia/aur-2024/aur241a.pdf
Ausina V, Prets G. Principales grupos de seres vivos con capacidadpatógena para el hombre. En: Ausina Ruiz V, Moreno GuillenS, editores. Tratado SEIMC de enfermedades infecciosas y microbiologíaclínica. Madrid: Médica Panamericana; 2005. pp. 1-18.
Mendez de Jesus IA, Esquivel-Chavez A, Gómez Flores S, SánchezHurtado L, Vázquez Rodríguez J, Arredondo Andrade S. Deltadel índice DvaCO2/DavO2 en las primeras 72 horas y la mortalidaden pacientes con choque séptico. Archivos Medicina de UrgenciasMéxico 2021.Vol. 13 Núm.2. Mayo-Agosto 2021 pp. 43-49.
Méndez de Jesus IA, Vázquez Hernández MI, Esquivel ChávezA, Molinar Ramos F, Canedo Castillo NA, Gómez Flores SS, et al.Sepsis: de la fisiopatología a la clinica. 1st ed. Mexico: EditorialPrado; 2022.
Reyes LF, Conway Morris A, Serrano-Mayorga C, Derde LPG,Dickson RP, Martin-Loeches I. Community-acquired pneumonia.Lancet. 2025 Nov 15;406(10517):2371-2388. doi: 10.1016/S0140-6736(25)01493-X. Epub 2025 Oct 16. PMID: 41110447.
Cohen J. The immunopathogenesis of sepsis. Nature. 2002Dec 19-26;420(6917):885-91. doi: 10.1038/nature01326. PMID:12490963.
Van der Poll T, Shankar-Hari M, Wiersinga WJ. The immunologyof sepsis. Immunity. 2021 Nov 9;54(11):2450-2464. doi: 10.1016/j.immuni.2021.10.012. PMID: 34758337.
Joo HK, Jeon BH. Endothelial Dysfunction: From Pathophysiologyto Novel Therapeutic Approaches 2.0. Biomedicines [Internet]2025 [consultado 13 de Jun 2016]; 13(11):2639. Disponible en:10.3390/biomedicines13112639
Jarczak D, Kluge S, Nierhaus A. Sepsis-Pathophysiology andTherapeutic Concepts. Front Med (Lausanne) [Internet] 2021[consultado
13 de Jun 2026]; 8:628302. Disponible en: 10.3389/fmed.2021.628302.13. Suzuki K, Miura T, Okada H. The endothelial glycocalyx-All thesame? No, it is not. Acute Med Surg [Internet] 2023 [consultado 13de Jun 2026];10(1): e896. Disponible en: doi: 10.1002/ams2.896.
Suzuki A, Tomita H, Okada H. La forma sigue a la función: el glicocálixendotelial. Transl Res [Internet] 2022 [consultado 13 de Jun2026];247: 158–167. Disponible en: https://www.translationalres.com/article/S1931-5244(22)00069-X/fulltext
Fernández-Sarmiento J, Salazar-Peláez LM, Carcillo JA. The EndothelialGlycocalyx: A Fundamental Determinant of Vascular Permeabilityin Sepsis. Pediatr Crit Care Med [Internet] 2020 [consultado13 de Jun 2026];21(5): e291-e300. Disponible en: 10.1097/PCC.0000000000002266.
Wang R, Han Q, Fan J, Xu Z, Liu W, Liu D, et al. Sepsis-InducedEndothelial Barrier Dysfunction: Mechanisms, Pathology,and Therapeutic Advances. Research (Wash D C) [Internet] 2025[consultado 16 de Jun 2026];8: 0997. Disponible en: 10.34133/research.0997.
Saavedra-Torres, JS, Castillo, LVA, Rendón, AM, Castro Valencia,DE, Lucero Guanga, DA, Garzón Ovalle, M., Arias Rodríguez,FD, López-Cortés, A., et al. From Glycocalyx Shedding to MicrovascularCollapse in Sepsis: Endothelial Pathophysiology, OrganDysfunction, and Mechanistic Biomarkers. Fisiopatología [Internet]2026 [consultado 16 de Jun 2026] 33 (2), 36. Disponible en:https://doi.org/10.3390/pathophysiology33020036
McMullan, RR, McAuley, DF, O›Kane, CM et al. Vascular leak insepsis: physiological basis and potential therapeutic advances.Crit Care [Internet] 2024 [consultado 16 de Jun 2026] ;28 , 97.Dsiponible en: https://doi.org/10.1186/s13054-024-04875-6
Dolmatova, EV, Wang,K, Mandavilli, R y Griendling, KK. Losefectos de la sepsis en el endotelio y sus implicaciones clínicas,Cardiovascular Research [Internet] 2021[consultado 16 de Jun
2026]; 117 (1), 60–73. Disponible en: https://doi.org/10.1093/cvr/cvaa07020. Wu M, Yan Y, Xie X, Bai J, Ma C, Du X. Effect of endothelialresponses on sepsis-associated organ dysfunction. Chin Med J(Engl) [Internet] 2024 [consultado 16 de Jun 2026]; 137(23):2782-2792. Disponible en:10.1097/CM9.0000000000003342.